seizure Flashcards by A S

Q

carbamazepine

A

leukopenia, aplastic anaemia, hepatic toxicity

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Q

lamotrigine

A

skin rash leading to Steven Johnsons syndrome

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Q

valproic acid

A

inhibit lamotrigine metabolism > result in prolonged half life

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Q

Phenytoin

A

long tern > hirsutism, coarsening of facial features, gingival hypertrophy, effects on bone metabolism

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Q

topiramate

A

significant psychomotor slowing

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Q

valproic acid

A

reversible bone marrow suppression, hepatotoxicity

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Q

Enzyme inducing drugs

A

Phenytoin, Carbamazepine, Oxcarbamazepine, Topiramate, Phenobarbital, Primidone
cause reversible deficiency of vitamin K dependent clotting factors in 50% new born
can decrease efficacy of OCP via enzyme induction

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