sensory-physio Flashcards
(24 cards)
Glycine is antagonized by …
Strychnine
Mechanism of action of GABA
Increase influx of cl and cause hyperpolarization inhibition
Norepinephrine effects
Stimulatory on alpha 1Inhibitory in beta 2 receptors
Effect of NO
Change intracellular metabolic function of the brain cells
Glutamate and aspartate receptors
NMDA , AMPA and kinate receptors
Muller’s law
Each receptor is specific to a certain stimulus and responds to it at low thersold• It can respond to non specific stimulus at high threshold by the same modality of sensation
Weber-fechner law
Frequency of AP from receptor to afferent directly proportional to logarithm of intensity on the receptor • If Frequency from recpetor to afferent was 10/100/1000The stimulus intensity on receptor ll be 1/2/3 in order
Skin over angle of mandible
Dermatome C2
Skin over sternal angle
T2
Skin around nipples
T 4
Skin over xiphoid process
T 7
Skin around umbilicus
T 10
Skin around symphysis pubis
T 12
Skin of axilla
T 1
Epicritic sensation
Fine touch Fast pain Fine degrees of temperatureStereognosisDeep pressureVibration
Protopathic sensations
Slow pain Crude touchCrude pressureWide degrees of temp.Itch and tickle
Absence sites if nociceptors
BoneBrain Liver parenchyma Lung alveoli Visceral layer of internal organs
Fast pain characters
A delta fibersOnly in skin No summationNT: glutamate Carried neo lateral spinothalamic tract
Slow pain characters
Afferent: c fibersNT : substance pTract: Paleo lat. spinothalamicSummated
1ry hyperalgesia
Mechanism: pain receptorsinflamed skin around an injury > non painful cause pain as touch Decreasing of thersold by chemical
2ry hyperalgesia
Mechanism: convergence facilitatory theory in spinal cord Pain stimulus with normal thersold become more painful in Normal healthy skin
Tic duoleureux
2ry hyperalgesiaSevere attack of pain of tg 5 and hypoglossal braches 9During laughing and swallowing like an electrical shock
Dynamic proprioceptionReceptors
Pacinian corpuscles: phasic receptors to detect initial rate of movementRuffiniGolgiMuscle spindleJoint receptors
Afferent of medial leminiscal pathway
A beta fibers