serological test for systemic autoimmune diseases Flashcards
(19 cards)
condition that occurs when a body’s immune response mistakenly attacks and destroys its own bbody tissues
autoimmune disease
there are at least __ autoimmune disorders, and their exact etiology is unknown
80
chronic multisystemic autoimmune disease where the immune system mistakenly assaults almost all health body organs
systemic lupus erythematosus
t/f: SLE can be difficult to detect because of the complexity of its clinical signs and symptoms, which appear gradually
t
test useful in screening patients suspected with SLE
antinuclear antibodies (ANA)
SLE slide test uses latex particles coated with antigens, such as __ or __, are mixed with a patient’s serum
deoxyribonucleoprotein (DNP) or native DNA (nDNA)
if the specific antinucler antibodies are present, visible aggregates resulting from the formation of Ag-Ab complexes will appear within __ minutes
2 minutes
positive
negative
non-organ specific type of autoimmune disorder
rheumatoid arthritis
condition affecting the lining of the joints (synovium), thereby causing painful swelling that can eventually lead to bone erosion and joint deformity
rheumatoid arthritis
t/f: the inflammation associated with RA can affect other body parts
t
a macroglobulin type, which is typically an IgM antibody but IgG and IgA isotypes may also occur
rheumatoid factor
autoantibody directed against the fc portion of an IgG
rheumatoid factor
RF is elevated in the blood and synovial fluid in __% of rheumatoid arthritis cases
75-85%
t/f: high levels of rf in blood is specific to ra only
f
normal rf value
0-20 U/mL
positive
negative
