Serrated Polyposis Syndrome

Question 1

Definition

Answer 1

condition characterized by the presence of multiple serrated polyps in the colon and rectum, and is associated with an increased risk of colorectal cancer (CRC).

Question 2

Diagnosis

Answer 2

كلمة السر 5
A diagnosis of SPS is made if any of the following criteria are met:

1. At least 5serrated polyps proximal to the rectum, all >5 mm in size, with at least two >10 mm.
2. More than 20 serrated polyps of any size, distributed throughout the colon, with at least 5 proximal to the rectum.
3. A first-degree relative diagnosed with SPS and at least one serrated polyp >5 mm proximal to the rectum.

Question 3

Management

Answer 3

1. Surveillance:

Colonoscopy every 1–3 years, depending on polyp burden.

Goal: detect and remove polyps early to prevent colorectal cancer.

2. Polypectomy:

Removal of all polyps ≥5 mm.

Consider piecemeal EMR for larger lesions.

3. Family Screening:

First-degree relatives should have screening colonoscopy starting at age 40 or 10 years younger than the earliest case in the family, repeated every 5 years if normal.

4. Surgery:

Consider subtotal colectomy with ileorectal anastomosis i