Serum tumor markers Flashcards Preview

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Flashcards in Serum tumor markers Deck (10):
1

Alkaline phosphatase

-Metastases to bone or liver
-Paget disease of bone
-seminoma (placental ALP).

2

α-fetoprotein

-Hepatocellular carcinoma
-hepatoblastoma
-yolk sac (endodermal sinus) tumor
-mixed germ cell tumor

*High levels associated with neural tube and abdominal wall defects

*low levels associated with Down syndrome.

3

β-hCG

*Hydatidiform moles and *Choriocarcinomas
(*Gestational trophoblastic disease)
-testicular cancer
-mixed germ cell tumor.

4

CA 15-3/CA 27-29

Breast cancer

5

CA 19-9

Pancreatic adenocarcinoma.

6

CA 125

Ovarian cancer

7

Calcitonin

Medullary thyroid carcinoma

8

CEA

CarcinoEmbryonic Antigen.

Very nonspecific but produced by ∼ 70% of colorectal and
pancreatic cancers

also produced by gastric,
breast, and medullary thyroid carcinomas

9

PSA

Prostate-specific antigen

Prostate cancer

Can also be elevated in BPH and prostatitis

Questionable risk/benefit for screening.

10

P-glycoprotein

AKA multidrug resistance protein 1 (MDR1)

Classically seen in *adrenal cell carcinoma but also expressed by other cancer cells (eg, colon, liver)

Used to pump out toxins, including chemotherapeutic agents (one mechanism of  responsiveness or resistance to chemotherapy over
time).