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Flashcards in Tumor suppressor genes Deck (15):
1

APC

Colorectal cancer (associated with FAP)

2

BRCA1/BRCA2

Breast and ovarian cancer

3

CDKN2A

Melanoma

pancreatic cancer

p16, blocks G1-->S phase

4

DCC

Colon cancer

DCC—Deleted in Colon Cancer

5

DPC4/SMAD4

Pancreatic cancer

DPC—Deleted in Pancreatic Cancer

6

MEN1

MEN 1

Menin

7

NF1

NeuroFibromatosis type 1

Ras GTPase activating protein (neurofibromin)

8

NF2

NeuroFibromatosis type 2

Merlin (schwannomin) protein

9

PTEN

Breast cancer

prostate cancer

endometrial cancer

10

Rb

Retinoblastoma

osteosarcoma

Inhibits E2F
blocks G1-->S phase

11

TP53

Most human cancers

Li-Fraumeni syndrome

p53, activates p21, blocks G1-->S phase

12

TSC1

Tuberous sclerosis

Hamartin protein

13

TSC2

Tuberous sclerosis

Tuberin protein

14

VHL

von Hippel-Lindau disease

renal cell carcinoma

Inhibits hypoxia inducible factor 1a

15

WT1/WT2

Wilms Tumor (nephroblastoma)