Session 12 - Neurotransmitters Flashcards

1
Q

Which NT may help decrease pain?

A

Adrenaline reduces the body’s ability to feel pain and increases momentary strength by triggering blood vessels to contract and re-direct blood toward major muscle groups, including the heart and lungs (fight or flight).

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2
Q

What does serotonin manage and control?

A
Digestion
Appetite
Social behaviour
Memory
Sleep
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3
Q

T/F neurons have direct contact with each other which is how they transfer information.

A

False - Neurons do not talk directly but use special chemicals called neurotransmitters. Communication between two neurons happens in the synaptic cleft (the small gap between the synapses of neurons).

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4
Q

Which NT is inhibitory in its action?

A

Glycine

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5
Q

Which NT is responsible for reward pathways and may help with addictions?

A

Dopamine - is the neurotransmitter related to feelings of pleasure. Its deficiency is associated with several mental health disorders (for example, eating disorders, non-suicidal self-injury, compulsive sex behaviours, internet gaming, gambling).

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6
Q

T/F Alanine is the amino acid precursor to Noradrenalin.

A

F – Tyrosine is.

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7
Q

A client is feeling mildly depressed and anxious. Which NT deficiency may be involved?

A

GABA is an inhibitory neurotransmitter of the brain that functions to inhibit excitatory signals and activity of the nervous system.

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8
Q

What does GABA help to do?

A
  • Reduce Anxiety

* Control motor function

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9
Q

Which nutrients are important for Serotonin production?

A

Tryptophan is converted to 5HTP, which is then converted to serotonin, this process requires:
Vitamin C, B6 and Zinc and cofactors

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10
Q

What are Neurotransmitters?

A

Molecules that communicate info between neurons and target cells at chemical synapses.
Our body’s chemical messengers

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11
Q

T/F the amino acid glutamate is required for GABA synthesis

A

This statement is true. GABA is synthesised from glutamate by the enzyme L-glutamic acid decarboxylase and uses pyridoxal phosphate (B6) as a cofactor.

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12
Q

T/F availability of choline and acetyl CoA is the limiting step in the formation of acetylcholine

A

True - Acetylcholine is synthesised from choline and acetyl coenzyme A (acetyl CoA) in nerve terminals.

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13
Q

T/F GABA is the NT associated with IBS diarrhoea

A

F- Serotonin is the neurotransmitter associated with IBS-diarrhoea.

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14
Q

Name the groups of neurotransmitters

A

Amino Acid neurotransmitters
Monoamines
Peptides & Other

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15
Q

Gives examples of amino NT’s (nervous system function)

A

Glutamate (+most common) excites
Gaba (inhibitory - brain).
Glycine (inhibitory - spinal cord).

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16
Q

Gives examples of monoamines NT’s

A
Serotonin
Histamine
Dopamine (catecholamine)
Epinephrine (catecholamine)
Norepinephrine (catecholamine)
17
Q

Give examples of peptides

A

Endorphin (perception of pain)

18
Q

Give examples of other NT’s

A

Acetylcholine (tells skeletal muscles to relax & contract - motor neurons)

19
Q

What are the 3 ways a neurotransmitter influences a neuron?

A

Excitatory - generates electrical signal (glutamate, acetylcholine, epinephrine, norepinephrine)
Inhibitory - prevents action potential (GABA, Glycine) modulatory.

20
Q

What are the main functions of glutamate?

A

Cognition, emotions, sensory info, perception

21
Q

What is the glutamate receptor that potentiates its functions.

A

NMDA - N-methyl-d-aspartate receptor

22
Q

T/F - Glutamate is toxic to neurons, and an excess will kill them.

A

True

23
Q

What nutrients are cofactors for NT’s production?

A

B Vitamins

24
Q

What is the cofactor for vitamin b6?

A

Pyridoxal-5-phosphate (P5P)

25
Q

What is GABA made from?

A

Glutamate in the presence of vit b6

26
Q

What nutrients does the body need to make GABA?

A

B3, B6, Taurine, Zinc, Magnesium, Glutamine, Probiotics

27
Q

What nutrients does the body need to make glutamate?

A

Manganese, Magnesium

28
Q

What symptom can too much Glutamate cause?

A

Brain fog

29
Q

What is Dopamine derived from?

A

Tyrosine

Precursor to tyrosine is phenylalanine

30
Q

What is dopamine a precursor to?

A

Epinephrine and norepinephrine

31
Q

What are catecholamines derived from?

A

L-tyrosine

32
Q

What is the most important enzyme involved in catecholamine synthesis?

A

Tyrosine hydroxylase catalyses the conversion of tyrosine in the presence of cofactors - tetrahydrobiopterin & molecular oxygen to L-DOPA.

33
Q

What is 5 hydroxy-tryptamine also known as?

A

Serotonin

34
Q

Poor memory is associated to what?

A

Low glutamate or noradrenaline