Session 3 AUTOIMMUNITY Flashcards Preview

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Flashcards in Session 3 AUTOIMMUNITY Deck (14):
1

What is autoimmunity and autoimmune disease 

We do have autoantibodies but they do not result in autoimmune disease 

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2

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3

Common autoimmune diseases and their target autoantigens clinical features

 

LO 

 

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4

Set of criteria for the diagnosis of a disease as autoimmune

 

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5

Autoimmune ( Immune response against the host due to the loss of immunological tolerance of self-antigen(s)) diseases produce ANTIBODIES (substances causing the autoimmune disease)

Which diseases have poor and good sensitivities?

Why may this test not be useful?

What do we mean by sensitivity? 

 

1. Pernicious anaemia has a poor sensitivity will have to see clinical manifestations aswell 

2. The production of autoantibodies are not always produced at the start of the disease 

Primary detected straight away
Secondary detected later on -> as produced later on?

3. Is the proportion of the people with the disease who are test positive -> detection rate

 

 

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6

The second criteria is we must locate these autoantibodies at their sites of tissue damage.

State the sites of tissue damage in these diseases.

State the technique we use to see if the autoantibody is there.

State how we get the tissue. 

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Can use patients tissues in biopsy’s to see if patients antibodies are there or

Can use FISH etc some markers

 

Pernicious anaemia use patients serum (containing autoantibody) to see if it binds to the rat stomach 

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7

Transfer of autoantibody or autoreactive T cells to a healthy host induces the autoimmune disease, how do we see this in humans? Give examples of the diseases.

 

IgG transfer during pregnancy and autoimmune diseases

In the diseases in the image below 

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8

Which disease is the most serious, state what disease would develop in the neonate 

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Thrombocytopenia 

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9

Breakdown of tolerance: Mechanisms of induction of autoimmunity not really important to know 

 

E.g. in the thymus where T cells develop failure to delete autoreactive T cells can be due to gene mutation

Most likely cause is breakdown of peripheral tolerance 

regulatory T cells defect - cytokinesis 

Altered self antigen due to infection 

 

B cells do not get activated need T cells to produce IgG (in some infectious cases can be activated by pathogens) 

carrier effect - infectious microbe/protein binds to host protein 

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10

What triggers autoimmunity?

 

Genetic factors

• Increased risk with an affected sibling (8X)

• Increased risk with an affected identical twin (30X) - also shows environmental factors are important as not 100% concordance

AIRE mutations (APECED syndrome) that affect central tolerance  (autoimmune regulatory 

• Autoimmune disease associated with MHC variants (HLADR3/DR4-highly associated with diabetes)

Environmental factors

• Hormones - women higher prevalence 

• Infections

11

Give examples of Infection-induced autoimmune disorders

 

ST.COCAM

Campylobacter jejuni -> main cause of food poisoning 

Coxsakieviruse

immune response to the microbial agent will get an immune response against the similar structure host protein 

IMMUNE SYSTEM IS MISLED BY MOLECULE OF MIMICRY 

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12

Drug-induced autoimmune syndromes

 

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13

Current and future therapeutic strategies for autoimmune diseases

 

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14

Mab means monoclonal antibody 
Zu means humanised 

 

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