Session 5_metastatic breast cancer

Question 1

CDK4/6 Inhibitors side effects

Answer 1

Neutropenia, fatigue, diarrhea

Question 2

Ovarian Suppression side effects

Answer 2

Exacerbation of menopausal symptoms, bone loss, sexual dysfunction

Question 3

mTOR inhibitor side effects

Answer 3

Stomatitis, pneumonitis, hyperglycemia, rash, fatigue

Question 4

PI3K inhibitor side effects

Answer 4

rash, diarrhea, hyperglycemia

Question 5

SERD side effects

Answer 5

hot flashes, arthralgias, hepatotoxicity, fatigue

Question 6

SERM side effects

Answer 6

hot flashes, VTE, endometrial ca

Question 7

Taxane Chemotherapy side effects

Answer 7

Myelosuppression, Neuropathy

Question 8

ADCs (T DxD, T-DM1) side effects

Answer 8

ILD/ pneumonitis (TDxD) thrombocytopenia, transaminitis, nausea,

Question 9

Tyrosine Kinase inhibitors side effects

Answer 9

Diarrhea, Hepatotoxicity

Question 10

PARP inhibitors side effects

Answer 10

anemia, neutropenia, nausea, thrombocytopenia, fatigue

Question 11

VEGF inhibitor side effects

Answer 11

Hypertension, proteinuria, fatigue, diarrhea, mucositis, bleeding, impaired wound healing

Question 12

What type of metastatic breast cancer receptor profile has the worst prognosis?

Answer 12

Triple Negative Breast Cancer

Question 13

What is an example of a CDK4/6 inhibitor

Answer 13

Palbociclib, Ribociclib, Abemaciclib

Question 14

What is an example of a medication causing ovarian suppression?

Answer 14

Goserelin, Leuprolide

Question 15

What is an example of an mTOR inhibitor?

Answer 15

Everolimus

Question 16

What is an antibody drug conjugate and an example name?

Answer 16

Trastuzumab emtansine (T-DM1) or trastuzumab deruxtecan (T-DxD)

Question 17

What is a HER2 targeted therapy?

Answer 17

Trastuzumab, Pertuzumab

Question 18

What is an example of a SERD?

Answer 18

Fulvestrant

Question 19

What is an example of a SERM?

Answer 19

Tamoxifen, Raloxifene

Question 20

What is an example of a Taxane chemotherapy?

Answer 20

Paclitaxel, Docetaxel

Question 21

What is an example of a tyrosine kinase inhibitor?

Answer 21

Lapatinib, Erlotinib, Gefitinib

Question 22

What is an example of a PARP inhibitor?

Answer 22

Olaparib, Niraparib

Question 23

What is an example of a VEGF inhibitor?

Answer 23

Bevacizumab

Question 24

Why does metastatic breast cancer to the brain that is HER2 positive have a longer survival than hormone receptor positive or triple negative disease?

Answer 24

Because the treatments available have CNS activitiy, meaning it can cross the blood brain barrier

Question 25

When we think of overall survival in a patient with metastatic breast cancer, what is the 5 year survival rate?

Answer 25

35% (this is all populations of metastatic breast cancer)

Question 26

What type of metastatic breast cancer receptor profile has the BEST prognosis?

Answer 26

HER2+ and Hormone Receptor + particularly for a patient who receives standard of care therapies

Question 27

What does hormone receptor positive (or negative) breast cancer mean?

Answer 27

It expresses the Estrogen Receptor (ER +) and/or it expresses the Progesterone Receptor (PR+)

Question 28

Which type of metastases from the breast has the best prognosis? Bone, or Brain?

Answer 28

Bone

Question 29

Which type of metastases from the breast has the worst prognosis? Bone, or Brain?

Answer 29

Brain