Session 6 - Movement Of Ions And Molecules Through Membranes Flashcards

1
Q

What is the value of of Sodium ions in the Extracellular fluid as compared to the Intracellular fluid?

A

ECF -142 mEq/L
ICF - 10 mEq/L

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2
Q

What is the value of of potassium ions in the Extracellular fluid as compared to the Intracellular fluid?

A

ECF - 4 mEq/L
ICF - 140 mEq/L

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3
Q

What is the value of of proteins in the Extracellular fluid as compared to the Intracellular fluid?

A

ECF - 2 g/dl
ICF - 16 g/dl

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4
Q

What is the structure of charges on a cell at rest?

A

At rest, a normal, healthy cell is positively charged outside and negatively charged on the inside.

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5
Q

What is the importance of the resting cell being polarised i.e. positive outside and negative inside ?

A

It is critical for maintaining cell volume and enables cells to generate action potentials

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6
Q

What is the phospholipid bilayer of the cell membrane composed of?

A

Phospholipid molecules made up of a hydrophilic head and a hydrophobic tail.

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7
Q

What holds the phosphate head and the fatty acid tail of a phospholipid molecule together?

A

Glycerol

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8
Q

Name 3 types of proteins found as part of the cell membrane.

A

Surface proteins
Integral proteins/Globular proteins
Peripheral proteins

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9
Q

Which part of the cell membrane do lipid soluble molecules move through?

A

Phospholipids

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10
Q

Which part of the cell membrane do water soluble molecules move through?

A

Membrane proteins such as channels, gates and carriers

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11
Q

List 5 examples of non-polar molecules that move through the cell membrane.

A

Oxygen
Carbon dioxide
Lipids
Cholesterol
Steroids

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12
Q

What kind of molecules are lipid soluble?

A

Non-polar molecules

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13
Q

What kind of molecules are water soluble?

A

Ions and polar molecules

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14
Q

List 5 examples of water soluble molecules that move through the cell membrane.

A

NaCl
KCl
Glucose
Proteins
Calcium ions

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15
Q

How does water move through the cell membrane?

A

Through special protein channels called aquaporins.

Water molecules rapidly move through these channels in a single file.

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16
Q

What is the value of Na+ in intracellular fluid?

A

10 mmol/L

17
Q

What is the value of K+ in intracellular fluid?

A

140 mmol/L

18
Q

What is the value of Mg++ in intracellular fluid?

A

20 mmol/L

19
Q

What is the value of Cl- in intracellular fluid?

A

4 mmol/L

20
Q

What is the value of glucose in intracellular fluid?

A

0-1 mmol/L

21
Q

What is the value of proteins in intracellular fluid?

A

16 g/dL

22
Q

What are the factors that influence Vmax?

A
  1. Rate of conformational change
  2. Number of carriers available
  3. Saturation of carriers
23
Q

Name 6 factors that affect cell membrane permeability.

A
  1. Thickness of the membrane
  2. Lipid solubility
  3. Number of protein channels
  4. Temperature
  5. Molecular weight
  6. Surface area