Session 9 - Immunocompromised Host Flashcards
What is an immunocompromised host?
State in which the immune system is unable to respond appropriately and effectively to infectious microorganisms
What are the 4 types of defects that causes immunodeficiency?
B cells
Antibody
T cell
Phagocytic
What is an example of B cell defect?
X linked agammaglobulinaemia Briton’s disease, defect in B cell development
What are 4 defects in antibody production?
Common variable immunodeficiency Selective IgA deficiency IgG subclass deficiency Hyper-IgM syndrome
What is an example of combined B and T cell defects?
Severe combined immunodeficiency
What is 4 examples of T cell defects?
Di George syndrome CD3 deficiency MHC Class II deficiency MHC class I deficiency
What are 3phagocytic defects?
Defects in respiratory burst
Defect in fusion of lysosome or phagosomes
Defect in neutrophil production and chemotaxis
What are 4 signs of immunodeficiency?
Infections that are
Severe
Persistent
Unusual
Recurrent
What is primary immunodeficiency caused by?
Intrinsic gene defect causing missing protein, cells or non functional components
What is secondary immunodeficiency caused by?
Underlying disease or treatment leading to decrease production of function OR increase loss of immune components
What are the 2 defects that are highly suspected when onset is at less than 6 months?
T cell
Phagocyte defect
What are the 2 defects that are highly suspected when onset is at more than 6 months but less than 5 years old?
B cell antibody defect
Phagocyte defect
What are the 2 defects that come on after 5 years old?
B cell/antibody/complement
Secondary immunodeficiency
What kind of infections are commonly associated with complement deficiency?
Bacteria
What kind of infection is commonly associated with phagocytic defects?
Fungi infection by candida
