SFP: neoplasia Flashcards

(43 cards)

1
Q

What is neoplasia

A

An abnormal mass of tissue where the growth exceeds that of normal tissue

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2
Q

What is meant by the term parenchyma

A

neoplastic cells

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3
Q

what is meant by the term stroma

A

connective tissue and vessels

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4
Q

What is meant by benign tumors

A

Tumors that remain localized and cannot spread to other body sites. They do, however, have risk for malignant change. Patients generally survive, but they can occasionally have significant morbidity/mortality

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5
Q

What is meant by malignant tumors

A

Tumors that can spread to other body sites and are capable of invasion. These tend to be associated with higher levels of morbidity/mortality

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6
Q

What are adenomas

A

benign tumors of glandular tissue

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7
Q

what are lipomas

A

benign tumors of fatty cells

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8
Q

what are osteomas

A

benign tumors of bone

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9
Q

what are papillomas

A

benign tumors with finger-like projections

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10
Q

what is a squamous papilloma

A

a benign wart

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11
Q

what is a hemangioma

A

benign tumor of mesenchymal tissue filled with blood; does not turn into malignancy

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12
Q

what is a leiomyoma

A

benign lesions of smooth muscle; often seen in the uterus, GI, and lungs

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13
Q

if a malignant tumor is epithelial we call it a ___

A

carcinoma

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14
Q

if a malignant tumor is mesenchymal, we call it a ___

A

sarcoma

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15
Q

what is a hamartoma

A

Mass of disorganized tissue consisting of cells and tissues normally found in the area where the hamartoma occurs; these are neoplastic

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16
Q

what is a choristoma

A

congenital anomaly consisting of normal cells in an abnormal location; these are not neoplastic

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17
Q

what is differentiation

A

The extent to which neoplasms resemble their cells of origin both morphologically and functionally

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18
Q

what tends to be the differentiation pattern of benign tumors

A

they tend to be well differentiated

19
Q

what is anaplasia

A

A lack of differentiation/ poorly differentiated. Blastoma is an example.

20
Q

what is dysplasia

A

disorderly proliferation; an intermediate between normal and carcinoma

21
Q

differentiate between growth characteristics of benign vs malignant lesions

A

benign lesions tend to grow and push surrounding structures to the side

malignant lesions invade surrounding tissues

22
Q

Upon microscopic examination, how do features of benign lesions compare with that of normal tissue?

A

The structural elements tend to look similar; ex: things like ducts with hold the same shapes

23
Q

Are carcinomas or sarcomas more common

A

Carcinoma; this is because epithelial cells are constantly proliferating which leads to more potential for uncoordinated growth

24
Q

Necrosis is often associated with…

25
a loss of differentiation often indicates... (benign vs malignant)
malignant
26
what is pleomorphism
variability of size, shape, and appearance of cells or their nuclei
27
What factors predispose us to malignancy
environment, age, heredity, pre-neoplastic conditions
28
Contrast between indirect and direct chemical carcinogens
Direct are substances that are cancer-causing of their own and do not require chemical transformation, while indirect require some kind of conversion in the body to be carcinogenic
29
Chemotherapeutic drugs are an example of…
Direct chemical carcinogens
30
Polycyclic hydrocarbons are an example of…
Indirect chemical carcinogens
31
Aflatoxin B is an example of…
An indirect chemical carcinogen
32
What are some types of radiation associated with carcinogenesis
UV rays, X rays, nuclear fission (nuclear bombs), and radionuclides (miners and lung cancer)
33
What is cancer cachexia
Tumors can cause the host to lose weight without trying due to the tumors leeching resources
34
Small cell carcinoma produces…
ACTH and ACTH-like substance, mimicking Cushing’s
35
What is tumor grading
Determining the extent to which the architectural and cellular features of a tumor recapitulate the histology of the parent tissue
36
asbestos is associated with ___
mesothelioma
37
benzene is associated with
AML
38
beryllium is associated with
lung carcinoma
39
cadmium is associated with
prostate carcinoma
40
chromium is associated with
lung carcinoma
41
nickel is associated with
lung and ooropharengeal carcinoma
42
radon is associated with
lung carcinoma
43
vinyl chloride is associated with
hepatic angiosarcoma