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Flashcards in Sheehy Drugs Deck (15):
1

Empiric treatment bacterial meningitis

Cefotoxime/ceftriazone and vancomycin

2

What drug added in pts >50 w/ bacterial meningitis?

Ampicillin

3

Immunocompromised pts w/ bacterial meningitis get what?

Vancomycin + ampicillin + either cefepime or meropenem

4

Bacterial meningitis and beta-lactam allergy?

Vancomycin + moxiloxacin + trimethoprim-sulfamethoxazole

5

Main pathogens in brain abscess

Viridans strep and staph aureus

6

Treatment for brain abscess

Penicillin G

Methronidazole

Ceftriaxone

Ceftazidime, cefepime or meropenem

Vancomycin

7

Penicillin G and brain abscess

Covers mouth flora that can go to brain

8

Methronidazole and brain abscess

Selectively absorbed by anerobic bacteria

Toxic products taken into bacterial DNA

Readily penetrates brain abscess, but recommended to treat in combo with another agent

9

Adverse effects of metronidazole

Disulfiram-like effect (avoid alcohol)

Metallic taste

10

Ceftriaxone and brain abscess

Covers most aerobic and microaerobic strep (in place penicillin G)

11

Ceftazidime, cefepime, or metipenem and brain abscess

Used when brain abscess complicates neurosurgical procedure

Covers pseudomona aeruginosa

12

Vancomycin and brain abscess

Use until you rule out MRSA, then stop and use nafcillin or oxacillin instead

13

Subdural empyema-community acquired treatment

Cefotaxime or ceftriaxone, vancomycin, methronidazole

14

Subdural empyema- hospital acquired treatment

Meropenem, vancomycin

15

Cryptococcal meningoencephalitis treatment

Amphotericin B- membrane function

Flucytosine (5-fluocouracil)- nucleic acid synthesis

Fluconazole- ergosterol synthesis