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Sem. B - Pharmacology > Side Effects > Flashcards

Flashcards in Side Effects Deck (27)
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1

Amiodarone Hydrochloride

  • Bradycardia
  • Vasodilation causing hypotension, flushing
  • Bronchospasm
  • Arrhythmias - Torsades de pointes

2

Aspirin

  • Increased risk of gastric bleeding
  • Wheezing in some asthmatics

3

Atropine Sulfate

  • Dry mouth
  • Visual blurring
  • Pupil dilation
  • Confusion and occasional hallucinations
  • Tachycardia
  • Do not use small (<100mcg) doses as they may cause paradoxical bradycardia

4

Benzylpenicillin Sodium

None listed

5

Adrenaline 1:1000

None listed

6

Adrenaline 1:10,000

None listed

7

Chlorphenamine

  • Sedation
  • Dry mouth
  • Headache
  • Blurred vision
  • Urinary retention
  • Psychomotor impairment
  • Gastrointestinal disturbance
  • Convulsions(rare)

Children and elderly more likely to suffer side-effects

Warn anyone receiving chlorphenamine against driving or undertaking any other complex psychomotor task, due to the sedative and psychomotor side-effects

With the IV preparation, transient hypotension, central nervous system stimulation and irritant effects

8

Dexamethasone

  • Gastro intestinal upset
  • Hypersensitivity anaphylactic reaction

9

Diazepam

  • Respiratory/cardiovascular depression, especially in presence of alcohol or opioid drugs
  • Hypotension, particularly if pt moved from supine position
  • Light-headedness
  • Unsteadiness
  • Drowsiness
  • Confusion
  • Amnesia

10

Glucose 40% (oral gel)

None listed

11

Glucagon

  • Nausea
  • Vomiting
  • Abdominal pain in adults
  • Diarrhoea in children
  • Hypokalaemia
  • Hypotension in adults
  • Acute hypersensitivity reaction (rare)

12

Glucose 10%

None listed

13

Glyceryl Trinitrate (GTN)

  • Headache
  • Dizziness
  • Hypotension

14

Hydrocortisone

  • Stinging or burning sensations

15

Ibuprofen

  • Nausea
  • Vomiting
  • Tinnitus

16

Ipratromium Bromide

  • Nausea
  • Dry mouth(common)
  • Tachycardia/arrhythmia
  • Paroxysmal tightness of the chest
  • Allergic reaction

17

Morphine Sulfate

  • Respiratory depression
  • Cardiovascular depression
  • Nausea
  • Vomiting
  • Drowsiness
  • Pupillary constriction

18

Naloxone Hydrochloride (Narcan)

  • In patients who are physically dependant on opioids, naloxone may precipitate violent withdrawal symptoms, including cardiac arrhythmias. It is better, in these cases, to titrate the dose of naloxone, effectively reversing the cardiac and respiratory depression, but still leaving the patient in a ‘groggy’ state, with regular reassessment of ventilation and circulation.
  • Vomiting

19

Nitrous Oxide (Entonox)

Minimal side effects

20

Ondansetron

  • Hiccups
  • Constipation
  • Flushing
  • Hypotension
  • Chest pain
  • Arrhythmias
  • Bradycardia
  • Headache
  • Seizures
  • Movement disorders
  • Injection site reactions

21

Oxygen

  • Non-humidified O2 is drying and irritating to mucous membranes over a period of time
  • In patients with COPD there is a risk that even moderately high doses of inspired oxygen can produce increased CO2 levels which may cause respiratory depression, which could lead to respiratory arrest

22

Paracetamol

...are extremely rare

Occasionally IV paracetamol may cause hypotension if administered too rapidly

23

Salbutamol

  • Tremor (shaking)
  • Tachycardia
  • Palpitations
  • Headache
  • Feeling of tension
  • Peripheral vasodilation
  • Muscle cramps
  • Rash

24

Sodium Chloride 0.9%

  • Over-infusion may precipitate pulmonary oedema and cause breathlessness

25

Syntometrine

  • Nausea
  • Vomiting
  • Abdominal pain
  • Headache
  • Hypertension
  • Bradycardia
  • Chest pain
  • Anaphylactic reactions(rare)

26

Tranexamic acid

Common:

  • Nausea
  • Vomiting
  • Diarrhoea

Serious:

  • Hypersensitivity reactions including anaphylaxis
  • Rapid injection may cause hypotension
  • Arterial or venous embolism at any site

27

Midazolam (pt own)

  • Respiratory depression
  • Hypotension
  • Reduced level of consciousness leading to impaired airway control
  • Confusion leading to increased agitation
  • Amnesia in some pt