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Flashcards in Sindromes Medulares Deck (7)
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1
Q

Como definir o nivel de uma lesão medular?

A

Sensory loss below this level is the result of damage to the spinothalamic tract on the opposite side one to two segments higher in the case of a unilateral spinal cord lesion, and at the level of a bilateral lesion. The discrepancy in the level of a unilateral lesion is the result of the course of the second-order sensory fibers, which originate in the dorsal horn, and ascend for one or two levels as they cross anterior to the central canal to join the opposite spinothalamic tract. Lesions that transect the descending corticospinal and other motor tracts cause paraplegia or quadriplegia with heightened deep tendon reflexes, Babinski signs, and eventual spasticity (the upper motor neuron syndrome). Transverse damage to the cord also produces autonomic disturbances consisting of absent sweating below the implicated cord level and bladder, bowel, and sexual dysfunction.

2
Q

Quais as principais síndromes medulares?

A

(1) Brown-Sequard Hemicord Syndrome This consists of ipsilateral weakness (corticospinal tract) and loss of joint position and vibratory sense (posterior column), with contralateral loss of pain and temperature sense (spinothalamic tract) one or two levels below the lesion. Segmental signs, such as radicular pain, muscle atrophy, or loss of a deep tendon reflex, are unilateral. Partial forms are more common than the fully developed syndrome.
(2) Central Cord Syndrome This syndrome results from selective damage to the gray matter nerve cells and crossing spinothalamic tracts surrounding the central canal. In the cervical cord, the central cord syndrome produces arm weakness out of proportion to leg weakness and a “dissociated” sensory loss, meaning loss of pain and temperature sensations over the shoulders, lower neck, and upper trunk (cape distribution), in contrast to preservation of light touch, joint position, and vibration sense in these regions. Spinal trauma, syringomyelia, and intrinsic cord tumors are the main causes
(3) Anterior Spinal Artery Syndrome Infarction of the cord is generally the result of occlusion or diminished flow in this artery. The result is extensive bilateral tissue destruction that spares the posterior columns. All spinal cord functions—motor, sensory, and autonomic— are lost below the level of the lesion, with the striking exception of retained vibration and position sensation.

3
Q

Qual a primeira etapa frente uma mielopatia aguda?

A

DISTINGUISHING COMPRESSIVE FROM NONCOMPRESSIVE MYELOPATHY
The first priority is to exclude a treatable compression of the cord by a mass. The common causes are tumor, epidural abscess or hematoma, herniated disk, or vertebral pathology. Epidural compression due to malignancy or abscess. MRI with gadolinium infusion, centered on the clinically suspected level, is the initial diagnostic procedure; in some cases it is appropriate to image the entire spine (cervical through sacral regions) to search for additional clinically silent lesions. Once compressive lesions have been excluded, noncompressive causes of acute myelopathy that are intrinsic to the cord are considered, primarily vascular, inflammatory, and infectious etiologies.

4
Q

Como tratar abcesso espinhal epidural?

A

(1) Surgical evacuation prevents development of paralysis and may improve or reverse paralysis in evolution, but it is unlikely to improve deficits of more than several days duration.
(2) Broad-spectrum antibiotics should be started empirically before surgery and then modified on the basis of culture results; medication is continued for at least 4 weeks. If surgery is contraindicated or if there is a fixed paraplegia or quadriplegia that is unlikely to improve following surgery, long-term administration of systemic and oral antibiotics can be used; in such cases, the choice of antibiotics may be guided by results of blood cultures. However, paralysis may develop or progress during antibiotic therapy; thus, initial surgical management remains the treatment of choice unless the abscess is limited in size and causes few or no neurologic signs.
(3) With prompt diagnosis and treatment of spinal epidural abscess, up to two-thirds of patients experience significant recovery.

5
Q

Qual o tratamento da síndrome de compressão medular neoplásica?

A

Management of cord compression includes (1) glucocorticoids to reduce cord edema, (2) local radiotherapy (initiated as early as possible) to the symptomatic lesion, and (3) specific therapy for the underlying tumor type.

(1) Glucocorticoids (dexamethasone, up to 40 mg daily) can be administered before the imaging study if the clinical suspicion is strong Continued at a lower dose until (2) radiotherapy (generally 3000 cGy administered in 15 daily fractions) is completed. Radiotherapy appears to be effective even for most classically radioresistant metastases. A good response to radiotherapy can be expected in individuals who are ambulatory at presentation. Surgery, either decompression by laminectomy or vertebral body resection, is usually considered when signs of cord compression worsen despite radiotherapy, when the maximum tolerated dose of radiotherapy has been delivered previously to the site, or when a vertebral compression fracture or spinal instability contributes to cord compression.
(3) Treatment usually prevents new weakness, and some recovery of motor function occurs in up to onethird of treated patients. Motor deficits (paraplegia or quadriplegia), once established for >12 h, do not usually improve, and beyond 48 h the prognosis for substantial motor recovery is poor. Although most patients do not experience recurrences in the months following radiotherapy.

6
Q

Como fazer a avaliação de uma mielopatia transversa aguda?

A

(1) MRI of spinal cord with and without contrast (exclude compressive causes).
(2) CSF studies: Cell count, protein, glucose, IgG index/ synthesis rate, oligoclonal bands, VDRL; Gram’s stain, acid-fast bacilli, and India ink stains; PCR for VZV, HSV-2, HSV-1, EBV, CMV, HHV-6, enteroviruses, HIV; antibody for HTLV-I, Borrelia burgdorferi, Mycoplasma pneumoniae, and Chlamydia pneumoniae; viral, bacterial, mycobacterial, and fungal cultures.
(3) Blood studies for infection: HIV; RPR; IgG and IgM enterovirus antibody; IgM mumps, measles, rubella, group B arbovirus, Brucella melitensis, Chlamydia psittaci, Bartonella henselae, schistosomal antibody; cultures for B. melitensis. Also consider nasal/pharyngeal/anal cultures for enteroviruses; stool O&P for Schistosoma ova.
(4) Immune-mediated disorders: ESR; ANA; ENA; dsDNA; rheumatoid factor; anti-SSA; anti-SSB, complement levels; antiphospholipid and anticardiolipin antibodies; p-ANCA; antimicrosomal and antithyroglobulin antibodies; if Sjögren syndrome suspected, Schirmer test, salivary gland scintography, and salivary/lacrimal gland biopsy.
(5) Sarcoidosis: Serum angiotensin-converting enzyme; serum Ca; 24-h urine Ca; chest x-ray; chest CT; total body gallium scan; lymph node biopsy.
(6) Demyelinating disease: Brain MRI scan, evoked potentials, CSF oligoclonal bands, neuromyelitis optica antibody (anti-aquaporin-4 [NMO] antibody).
(7) Vascular causes: CT myelogram; spinal angiogram.

7
Q

Qual o manejo da siringomielia?

A

(1) Treatment of syringomyelia is generally unsatisfactory.
(2) The Chiari tonsillar herniation is usually decompressed, generally by suboccipital craniectomy, upper cervical laminectomy, and placement of a dural graft. Obstruction of fourth ventricular outflow is reestablished by this procedure. If the syrinx cavity is large, some surgeons recommend direct decompression or drainage by one of a number of methods, but the added benefit of this procedure is uncertain, and morbidity is common. With Chiari malformations, shunting of hydrocephalus should generally precede any attempt to correct the syrinx. Surgery may stabilize the neurologic deficit, and some patients improve
(3) Syringomyelia secondary to trauma or infection is treated with a decompression and drainage procedure in which a small shunt is inserted between the syrinx cavity and the subarachnoid space; alternatively, the cavity can be fenestrated.
(4) Cases due to intramedullary spinal cord tumor are generally managed by resection of the tumor.