SIRS Flashcards
SIRS
Uncontrolled inflammatory response syndrome resulting from systemic mediator release
infection
host response to presence of microorganisms or tissue invasion of microorganisms
septicemia
presence of microbes in the blood
4 S/S SIRS
temp >38
HR >90
Resp rate>20
WBC count >12k, <4k
Why do micro thrombi form in sepsis/how they impair blood flow
cellular mediators shift to producing pro thrombic, anti fibrinolytic activity
why does vascular permeability increase
vascular endothelial cells pull away from eachother
why is there widespread vasodilation in SIRS
decreased vascular tone
how does SIRS affect CO
Less preload due to decreased venous return = less SV/CO
how does fever affect O2 supply
increases metabolism, so O2 demand increases
Why does tachypnea occur in SIRS
Compensation to meet inc O2 demands
Buffer metabolic acidosis
why do some patients with SIRS have regular BP
If sepsis is mild, patients can compensate. Increasing HR will noramlize CO, maintaining normal BP for some time
when does compensation for low BP stop
inflammatory response worsens, so vasodilation, vascular permeability and plasma leakage worsens. Fluid shifts into interstitial space
what lines of defense are innate immune response
first and second lines of defense
first line of defense is ?
Physical barriers
what physical barriers make up first line of defense
skin, mucous/cilia, tears, normal flora, urine flow
