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Flashcards in SIRS and sepsis Deck (19)
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1
Q

what is SIRS?

A

systemic inflammatory response syndrome

2
Q

SIRS is defined as two out of list of what things?

A

Heart rate >90
resp rate >20
temperature <36 or more 38
WCC <400 or more 12000

3
Q

what is sepsis defined as?

A

SIRS with a suspicion of infection

4
Q

what is severe sepsis ?

A
sepsis with end organ dysfunction 
resp:ARDS 
CVS: hypotension 
renal : oliguria and AKI 
Hepatic: altered LFT and coagulation 
haematological: DIC, thrombocytopaenia 
CNS: confusion, altered GCS
unexplained metabolic acidosis
5
Q

severe sepsis -resp

A

ARDS

6
Q

what is septic shock?

A

severe sepsis with hypotension that is refractory to fluid resuscitation

7
Q

what is the sepsis 6?

A
give 3 take 3 
give 3 
Fluids (500ml saline stat) 
Oxygen 94-98% 
IV antibiotics (AGM/VGM if penicillin allergic)
8
Q

what 3 do you take?

A

urine output (catheterise)
blood cultures
lactate

9
Q

what antibiotics work on the wall but not a b lactam?

A

vancomycin

10
Q

name an aminoglycoside

A

gentamycin

11
Q

gentamicin shouldn’t be given for more than ?

A

3 days

12
Q

quinolone?

A

ciprofloxacin, ofloxacin

13
Q

examples of macrolides?

A

clarithromycin
erythromycin
azithromycin

14
Q

what type of bacteria is doxycycline?

A

tetracyclines (4 counties)

15
Q

does doxycycline over gram -ve or positive?

A

positive

16
Q

tetracycline which is associated with c diff?

A

clindamycin

17
Q

which antibiotic can interact with the COCP? why?

A

rifampicin - its a liver enzyme inducer

reduces contraceptive effect of the pill

18
Q

which antibiotics increase plasma concentrations of theophylline? what can this cause/

A

macrolides. this can cause seizures

19
Q

what antibodies can increase chance of myopathy when taken with statins?

A

macrolides

especially clarithromycin and simvastatin