Skeletal muscle physiology Flashcards

(35 cards)

1
Q

What are the three types of muscle?

A

Smooth, cardiac, skeletal

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2
Q

Which muscle types are striated?

A

skeletal and cardiac

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3
Q

Cardiac muscle is subject to voluntary control. TRUE OR FLASE

A

False- skeletal muscle is subject to voluntary control

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4
Q

What initiated skeletal muscle contraction?

A

motor neurone stimulation (neurogenic mechanisms)

as they are innervated by the somatic nervous system

Neuromuscular junctions present-NO gap junctions

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5
Q

What are skeletal muscle fibres organised into?

A

motor units

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6
Q

What does the number of muscle fibres per motor unit depend on

A

the function served by the muscle

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7
Q

What is a sarcomere and where is it found?

A

the functional unit of skeletal muscle

found between two Z lines

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8
Q

What is a motor unit

A

a single alpha motor neuron and all the skeletal muscle fibres it innervates

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9
Q

What are cardiac and smooth muscle innervated by?

A

autonomic nervosa system- involuntary

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10
Q

What are the dark and light bands visible under a light microscope

A

dark- caused by myosin thick filaments

light- caused by actin thin filaments

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11
Q

What initiates cardiac muscle contraction?

A

Myogenic (pacemaker potential) initiation of contraction

No neuromuscular junction but GAP JUNCTIONS PRESENT

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12
Q

In skeletal and cardiac muscle where is the Ca++ from?

A

skeletal- Ca++ entirely from sarcoplasmic reticulum

Cardiac- Ca++ from ECF and sarcoplasmic reticulum

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13
Q

What does the graduations of contraction depend on in skeletal muscle?

A

1- motor unit recruitment

2-summation of contractions

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14
Q

What does cardiac muscle graduations of contraction depend on?

A

The extent of heart filling with blood( preload) - Frank-starling mechanism

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15
Q

There is continuity of cytoplasm between nerve and skeletal muscle cells . TRUE or FALSE

A

false- there is no continuity of cytoplasm between nerve and skeletal muscle cells. Acetylcholine is the transmitter at neuromuscular junction

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16
Q

Give 3 examples of places where there are fewer fibres per motor unit and why?

A

they serve fine movements

external eye muscles
muscles of facial expression
intrinsic hand muscles

17
Q

Give 3 examples of places where there are fewer fibres per motor unit and why?

A

they serve fine movements(~10 fibres per motor unit)

external eye muscles
muscles of facial expression
intrinsic hand muscles

18
Q

Give an example of where Power is more important than precision and how many fibres per motor unit does the muscle have?

A

Thigh muscle

hundreds to thousands fibres per motor unit

19
Q

muscles are attached to bones via

20
Q

What is the functional unit of any organ?

A

the smallest component capable of performing all the functions of the organ

21
Q

What are the four zones the sarcomere?

A

A-band
H-zone
M-line
I-band

22
Q

What is the A-band?

A

Made up of thick filaments along with portions of thin filaments that overlap in both ends of thick filaments

23
Q

What is the H-zone?

A

Lighter area within middle of A-band where thin filaments don’t reach

24
Q

What is the M-line?

A

Extends vertically down middle of A-band within the centre of H-zone

25
What is the I-band?
Consists of remaining portion of thin filaments that do not project into A-band
26
Muscle tension is produced by sliding of myosin filaments over actin filaments TRUE OR FLASE
False- muscle tension is produced by sliding of actin filaments on myosin filaments
27
Force generation depends upon ________ ______ between thick (myosin) and thin (actin) filaments
ATP-dependent interaction
28
TRUE OR FLASE | ATP is required for both contraction and relaxation
TRUE
29
Ca++ is required to switch __ cross bridge formation
on
30
What is excitation contraction coupling
the process whereby the surface action potential results in activation the contractile structures of the muscle fibre
31
In the skeletal muscle fibres where is the Ca++ released from?
the lateral sacs of the sarcoplasmic reticulum
32
Where does the surface action potential spread down to?
transerve (T) tubules | - these are extensions of the surface membrane that dip into the muscle fibre
33
What does Ca++ bind to and what does this result in
binds to troponin- this results in repositioning of troponin-tropomyosin complex to uncover the cross-bridge binding sites on actin
34
What is the transmitter at the neuromuscular junction?
acetylcholine
35
Why is ATP needed during muscle contraction and relaxation
during muscle contraction- to power cross bridges | during relaxation- to release cross bridges and to pump Ca++ back into the sarcoplasmic reticulum