Skeletal muscle relaxant drugs

Question 1

atracurium

Answer 1

• nondepolarizing blocker of the NMJ
• prevents access of ACh to its receptor
• risk of bronchospasm

Question 2

cisatracurium

Answer 2

• nondepolarizing blocker of the NMJ
• prevents access of ACh to its receptor
• risk of bronchospasm

Question 3

mivacurium

Answer 3

• nondepolarizing blocker of the NMJ
• prevents access of ACh to its receptor
• risk of bronchospasm

Question 4

d-tubocurarine

Answer 4

• nondepolarizing blocker of the NMJ
• prevents access of ACh to its receptor
• risk of bronchospasm

Question 5

pancuronium

Answer 5

• nondepolarizing blocker of the NMJ
• prevents access of ACh to its receptor
• risk of bronchospasm

Question 6

pipercuronium

Answer 6

• nondepolarizing blocker of the NMJ
• prevents access of ACh to its receptor
• risk of bronchospasm

Question 7

rocuronium

Answer 7

• nondepolarizing blocker of the NMJ
• prevents access of ACh to its receptor
• risk of bronchospasm

Question 8

vecuronium

Answer 8

• nondepolarizing blocker of the NMJ
• prevents access of ACh to its receptor
• risk of bronchospasm

Question 9

succinylcholine

Answer 9

• depolarizing blocker of NMJ
• activates ACh receptor and keeps channel open
• very short acting

Question 10

ambenzonium

Answer 10

• AChE inhibitor

- used for myasthenia gravis, dementia

Question 11

donepezil

Answer 11

• AChE inhibitor

- used for myasthenia gravis, dementia

Question 12

echothiophate

Answer 12

• AChE inhibitor

- used for myasthenia gravis, dementia

Question 13

edrophonium

Answer 13

• AChE inhibitor

- used for myasthenia gravis, dementia

Question 14

galantamine

Answer 14

• AChE inhibitor

- used for myasthenia gravis, dementia

Question 15

neostigmine

Answer 15

• AChE inhibitor

- used for myasthenia gravis, dementia

Question 16

physostigmine

Answer 16

• AChE inhibitor

- used for myasthenia gravis, dementia

Question 17

pyridostigmine

Answer 17

• AChE inhibitor

- used for myasthenia gravis, dementia

Question 18

rivastigmine

Answer 18

• AChE inhibitor

- used for myasthenia gravis, dementia

Question 19

tacrine

Answer 19

• AChE inhibitor

- used for myasthenia gravis, dementia

Question 20

atropine

Answer 20

-Muscarinic ACh receptor blocker

Question 21

glycopyrrolate

Answer 21

-antimuscarinic

Question 22

pralidoxime

Answer 22

• AChE regenerator

- used to treat the toxic inhibition of AChE inhibitors like organophosphates

Question 23

baclofen

Answer 23

• GABAb agonist
• spasmolytic drug
• results in inhibition of excitatory neurotransmitter release

Question 24

carisprodol

Answer 24

• MOA unknown

- spasmolytic, anxiolytic

Question 25

cyclobenzaprine

Answer 25

- MOA unknown | - spasmolytic, drowsiness

Question 26

diazepam

Answer 26

- GABAa receptor agonist - spasmolytic drug - increases effect of GABA on its receptor

Question 27

tizanidine

Answer 27

- α2 agonist | - spasmolytic drug

Question 28

dantrolene

Answer 28

- blocks Ca+ release from SR by blocking RYR | - used to treat malignant hyperthermia

Question 29

botox

Answer 29

- cleaves the VAMP and blocks vesicle fusion to presynaptic membrane - spasmolytic agent

Question 30

glucocorticoids

Answer 30

- MS treatment | - immunosuppressive

Question 31

glatiramer acetate

Answer 31

- MS treatment | - activate T lymphocyte suppressor cells

Question 32

IFN-β

Answer 32

- MS treatment | - inhibit T lymphocyte adhesion to BBB

Question 33

mitoxantrone

Answer 33

- MS treatment - antineoplastic - intercalates into DNA and causes strand breaks and cross links