Sketchy Cholinergic Flashcards
(84 cards)
1
Q
Acetyl-Cola Sign
A
ACh receptor agonist
2
Q
Mime drinking cola
A
Cholinomimetrics
3
Q
Smoker
A
Nicotinc ACh receptor
4
Q
Outlet near smoker
A
Nicotinic ACh receptors found on motor end plate on skeletal muscle NMJ
5
Q
Transformers
A
Nicotinic ACh receptors found on autonomic ganglia
6
Q
Beanie
A
Nicotinic ACh receptors found on adrenal gland
7
Q
Motorcycle parking spots
A
Muscarinic ACh receptor
8
Q
Ion channel news behind smoker
A
Nicotinic receptors are Na channels
9
Q
QIQ Mart
A
M1-Gq ; M2-Gi; M3-Gq
10
Q
Dogs in M1/M3 motorcycles
A
Gq activates IP3-DAG cascade - increased Ca
11
Q
Packed up tent in M2 motorcycle
A
Gi decreases cAMP
12
Q
Brain Helmet on M1
A
M1 receptors found in nerves/CNS
13
Q
Top of Heart with Jewels on M2
A
M2 receptors found in atria, SA node, AV node
14
Q
Glandular Sponge
A
M3 receptors on glands
15
Q
Smooth muscle stripes
A
M3 receptors on smooth muscle
16
Q
NO exhaust pipe
A
M3 activation leads to NO release, increased cGMP and vasodilation; opposite in damaged endothelial
17
Q
Beth Construction worker with Cola
A
Bethanechol - cholinomimetric
18
Q
Cement from colon spout
A
muscarinic agonists increase secretion/motor activity of gut
19
Q
Do not obstruct sign
A
Bethanechol is used to treat non-obstructive GI dysmotility (post-op ileus, neurogenic ileus)
20
Q
Water hose
A
Bethanechol treates urinary retention
21
Q
Pile o’carp
A
Pilocarpine - cholinomimetric
22
Q
Dripping carp mouths
A
Pilocarpine increases salivation
23
Q
Round glass above nets
A
muscarinic agonists cause accommodation of lens
24
Q
Smooth muscle crane with net zonules
A
Pilocarpine contracts ciliary muscle to increase aqueous humor outflow and decrease intraocular pressure (glaucoma)
25
Fisherman with constricted hood
pilocarpine activates sphincter pupillae to cause pupillary constriction - miosis (acute glaucoma)
26
Resident above QIQ Mart
Carbachol
27
Constricted hood blocking carbon fumes
Carbachol causes pupillary constriction (narrow angle glaucome)
28
Carbon fumes
Carbachol is muscarinic and nicotinic agonist
29
Marathon
Methacholine - cholinomimetic
30
Challenge
Metacholine challenge instigates asthma for pulmonary testing
31
Wheezing Man
cholinomimetrics contract bronchial smooth muscle which exacerbates asthma/COPD
32
Acetyl-Cola Mime through smog
Indirect cholinomimetics inhibit AChE
33
Dumpster of acetyl-cola
AChE degrades ACh
34
Knocked over dumpster of acetyl-cola
AChE inhibitors increase concentration of ACh
35
Anti-Establishment graffiti
Anticholinesterase (AChE inhibitor)
36
Stigma graffiti
"stigmine" drug suffix of AChE inhibitors
37
Skeletal muscle brick wall
AChE inhibitors enhance ACh effects at NMJ by increasing nicotinic ACh receptor activty
38
Grave graffiti
myasthenia gravis - antibodies against nicotinic ACh receptors at motor endplate of skeletal muscle NMJ; patient presents with ptosis, diplopia, difficulty swallowing, proximal limb weakness (progressive)
39
Community PRIDE worker removing graffiti
Pyridostigmine - AChE inhibitor used as long term treatment for MG by increasing ACh concentration at NMJ
40
Neon sign Stigma
Neostigmine - AChE inhibitor used as treatment for MG
41
Phone Booth
Edrophonium - AChE inhibitor that transiently reverses MG symptoms (short acting)
42
Quarters only
Pyridostigmine, neostigmine, edrophonium are quaternary amines and do not penetrate CNS
43
Working Phone
Edrophonium reverses muscle weakness in undertreated MG patients (Positive tensilon test)
44
Out of order phone with anti-esterase graffiti
edrophonium fails to reverse muscle weakness and exacerbates cholinergic crisis
45
CURARE crayons stuck in end plate
nondepolarizing neuromuscular blocking agents (tubocurarine) inhibit nicotinic ACh receptors at NMJ endplate
46
Neon sign store owner kicking out CURARE crayon kid
AChE inhibitors reverse nondepolarizing neuromuscular blockade
47
SUCKS graffiti
Succinylcholine is depolarizing neuromuscular blocking agent (nicotinic ACh receptor agonist)
48
Phase-1 cleanup crew getting shocked
initial phase-1 of depolarizing blockade is IRREVERSIBLE (AChE inhibitors potentiate blockade)
49
Bladder hose
AChE inhibitors used to treat urinary retention (muscarinic activation)
50
PHYS ED center
PHYSostigmine (AChE inhibitor with Central effects)
51
Atropine in Wonderland graffiti
Atropine overdose - reversed by Physostigmine
52
Flower
belladonna flower in naturally occurring form of atropine - patient presents working in garden
53
Phys Ed teacher reprimanding atropine artist
Physostigmine reverses atropine overdose (peripheral and central effects)
54
Your brain on drugs
Physostigmine (and organophosphates) enter CNS to cause central cholinergic effects
55
DUMBBELSS
Diarrhea, urination, miosis, bronchospasm, bradycardia, excitement of CNS, lacrimation, salivation, sweating
56
Weak nicotine kid
AChE inhibitor toxicity includes flaccid paralysis (NMJ nicotinic ACh receptor over-activation)
57
THIOL spray
insecticides are organophosphates - AChE inhibitor
58
Closing LID on TOXIC spray
praLIDoxime - reverses organophosphate toxicity (DUMBBELSS)
59
New toxic waste dumpsters
pralidoxime regenerates AChE at PERIPHERAL muscarinic and nicotinic receptors - reduces cholinergic toxicity including flaccid paralysis
60
Atropine Alice is in your head
atropine reverses both peripheral/central muscarinic toxicity from organophosphate poisoning but not paralysis
61
Old pest control man
"aging" of organophosphate cholinesterase complex leads to irreversible binding
62
Corroded dumpster
pralidoxime is ineffective once aging of complex has occurred
63
Done with brain puzzle
Donepezil - AChE inhibitor used to treat Alzheimer's
64
Motorcycle Parking spots
Muscarinic ACh receptors
65
Reverse parking in spot
Muscarinic antagonists reversibly block muscarinic receptors
66
Blocked tweedleDUMBBELSS
antimuscarinics block muscarinic effects of diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of CNS, lacrimation, salivation, sweat
67
Blocked acetyl-Cola bottle
antimuscarinics block action of ACh at M receptors
68
Alice
Atropine - antimuscarinic
69
Large pupil gazing into distance
antimuscarinics cause pupillary dilation (mydriasis) and cycloplegia (inabillity to accommodate lens for near vision - ciliary muscle)
70
Heart with jewel nodes
antimuscarinics block parasympathetic activation of M2 receptors on SA/AV nodes - increased HR, increased AV conduction
71
Elevated heart watch
antimuscarinics increase HR - treatment of bradycardia
72
Heart shield
heart block
73
Falling heart shields
antimuscarinics increase AV conduction - useful in treatment of heart block
74
Cat-ipra-tropillar
itrapropium - M3 muscarinic antagonist
75
Puffing
itrapropium is an inhaled antimuscarinic bronchodilator
76
Blue bloater with pink puffer
ipratropium is useful in management of COPD - antagonize M3 receptors causing bronchodilation and decreased secretions
77
Turning off bladder
treat incontinence - antagonize M3 receptors which relax smooth muscle in ureters and bladder wall
78
Parking Center sign over M1
M1 muscarinic receptors are found in CNS; M1 receptor antagonists can reduce tremors and rigidity in Parkinson's disease
79
Benz parked in M1
Benztropine - centrally acting M1 muscarinic antagonist
80
Shaking antenna
centrally acting antimuscarinics (benztropine) treat tremor/rigidity in Parkinson's by blocking excess cholinergic activity
81
Hot as a hare
antimuscarinics inhibit M3 receptors on sweat glands decreasing sweat - hyperthermia
82
Dry as a cracker
antimuscarinics decrease salivation and dry eyes
83
Blind as a bat
antimuscarinics cause mydriasis and cycloplegia - blurred vision
84
High pressure as a kettle
antimuscarinics cause mydriasis which decreases outflow of aqueous humor causing acute angle closure glaucoma
