Flashcards in Skin Deck (49):
Erythematous papules and plaques with characteristic silvery scaling
It demonstrates histologic epidermal proliferation with acanthosis and highly characteristic parakeratosis
Increased thickness of the stratum corneum
Hyperkeratosis with retention of nuclei of keratinocytes
Thickening of the epidermis
Epidermal intercellular edema with widening of intercellular spaces
Separation of epidermal cells, one from the other; cells appear to float within extracellular fluid
Accentuation of skin markings caused by scratching
The formation of severe intraepidermal bullae with prominent intraepidermal acantholysis, sparing of the basal layer and IgG autoantibodies directed against the epidermal intercellular cement substance are characteristics of this condition
Autoimmune disorder characterized by subepidermal bullae, with inflammatory infiltrate of eosinophils in the surrounding dermis and IgG autoantibodies directed against epidermal basement membrane.
Recurrent pruritic blistering disorder that is commonly associated with gluten-sensitive enteropathy (celiac disease)
It is most characteristically associated with a “target” lesion resembling an archer’s bull’s eye.
There is usually hypersensitivity to coexistent infectious agents, various drugs, a concomitant connective tissue disorder, or an associated malignancy.
A melanin dysfunction that is limited to the eyes.
A melanin synthetic defect that involves the eyes, skin, and hair
A melanin dysfunction that predisposes to actinic keratosis, basal and squamous cell carcinoma, and malignant melanoma because of sensitivity of skin to sunlight.
This acquired loss of melanocytes in discrete areas of skin appears as depigmented white patches.
May be autoimmune; abtimelanocyte antibodies
Produced by an increase of melanin pigment within basal keratinocytes.
A pigmented macule caused by melanocytic hyperplasia in the epidermis
Nevus that is present at birth characterized by nodular foci of dendritic, highly pigmented melanocytes in the dermis
Benign nevus characterized by spindle-shaped cells that may be confused for malignant melanoma
Spitz nevus (juvenile melanoma)
This is an atypical, irregularly pigmented lesion with disorderly proliferation of melanocytes, dermal fibrosis, and often subjacent dermal lymphocytic infiltration.
Transform into malignant melanoma
This irregular macular pigmented lesion on sun-exposed skin is characterized by atypical melanocytes at the epidermal–dermal junction.
Lentigo maligna (Hutchinson freckle)
Nonfamilial precursor of lentigo maligna melanoma
Umbilicated, dome-shaped papules are characteristics of thus contagious viral disorder.
Vacuolated cells (koilocytes) in the granular cell layer of the epidermis are characteristics of this viral disease
Verruca vulgaris (common wart)
Acrochordon (fibroepithelial polyp)
Intertwining bundles of collagen and fibroblasts are characteristics of this benign neoplasm of the skin
This extremely common benign neoplasm of older persons manifests as sharply demarcated raised papules or plaques with a typical pasted-on appearance; lesions occur on the head, trunk, and extremities.
Aka senile keratosis
The characteristic appearance of this low-grade variant of squamous cell carcinoma is of a dome-shaped nodule bearing a central crater filled with keratinaceous material.
This premalignant epidermal lesion is caused by chronic excessive exposure to sunlight.
This disorder is sometimes a marker of visceral malignancy (stomach, lung, breast, uterus) and is often seen in the setting of diabetes and other endocrinopathies.
Acanthosis and hyperpigmentation, most often involving flexural areas, are characteristic.
Small, blood-filled capillaries lined with a single layer of endothelium
Hemangioma chracterized by purple red-area on the face and neck
Port wine stain, a capillary hemangioma
Strawberry hemangioma: bright-red raised lesion
Cherry hemangioma: small, dome-shaped red papule
Large, endothelium-lined spaces in the dermis and subdermis
This disorder involves port-wine stain of the face, ipsilateral glaucoma, vascular lesions of ocular choroidal tissue, and extensive hemangiomatous involvement of meninges.
Clinical manifestations include convulsions, mental retardation, and retinal detachment.
Skin tumor that frequently originates in a preexisting actinic keratosis.
Squamous cell carcinoma
Skin malignancy that most often presents as a scaling, indurated, ulcerated nodule; invasion of dermis by sheets and islands of neoplastic epidermal cells, often with keratin “pearls,” is characteristic.
Squamous cell carcinoma
Involves usually the LOWER part of the face
BCC- involves the UPPER part of the face
The most common of all malignant skin tumors.
Basal cell carcinoma
Skin tumor that grossly presents as a pearly papule, often with overlying telangiectatic vessels; characterized by clusters of darkly staining basaloid cells with a typical palisade arrangement of the nuclei of the cells at the periphery of the tumor cell clusters
Basal cell carcinoma
The most important prognostic variable for malignant melanoma is
Growth phase of malignant melanoma that occurs in all directions but is predominantly lateral within the epidermis and papillary zone of the dermis.
Radial phase (initial)
Growth phase of malignant melanoma that extends into the reticular dermis or beyond
Vertical (later phase)
Growth phase of malignant melanoma that do not metastasize
Vertical phase - metastasis
Variant of melanoma that develops from preexisting Hutchinson freckle
Lentigo maligna melanoma
The most common of the variants of melanoma.
Superficial spreading melanoma
Variant of melanoma that has the poorest prognosis
begins with the vertical growth phase
Variant of melanoma that most often appears on the hands and feet of dark-skinned persons.
An aggressive neuroendocrine malignancy that typically arises on the head and neck skin of the elderly and grossly appears as a red or violaceous nodule or plaque.
Merkel cell carcinoma