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Histology > Skin > Flashcards

Flashcards in Skin Deck (15):
1

Q image thumb

A=epidermis

B=Dermis

C=Subcutaneous layer

D=Epidermal Ridges

E=Dermal Papillae

F=Tactile (sensory) receptor

G=Artery

H=Vein

I=Areolar Connective tissue

J=Adipose connective tissue

K=Papillary layer

L=Reticular layer

 

 

2

Cells in Epidermis

Keratinocytes (squamous cells)

Melanocytes-pigment producing

Langerhans-antigen presenting

Merkel-tactile

3

Q image thumb

A=Stratum Corneum

B=Stratum Lucidum

C=Stratum Granulosum

D=Stratum spinosum

E=Stratum Basale

F= Dermis

G=Dead Keratinocytes

H=Living Keratinocytes

I=Melanocyte

J=epidermal dendritic cell

K=basement membrane

L=tactile cell

M=sensory nerve ending

4

Stratum Basale

  • Intense mitotic activity, contains progenator cells for all of epidermis
  • Hemidesmosomes join cells to basal lamina
  • Desmosomes bind these cells together
  • Cells move upward during differentiation
  • Basal cell carcinoma, Melanoma, Merkel Cell Carcinoma

5

Stratum Spinosum

  • Thickest layer consisting of polyhedral cells
  • Thick skin (i.e. soles of feet) have a thicker layer of stratum spinosum
  • Squamous cell carcinoma

6

Stratum Granulosum

  • Three to five layers of flattened cells, undergoing the terminal differentiation process of keratinization

  • Cytoplasm is filled with keratohyaline granules and lamellar granules

  • The lamellar granules undergo exocytosis, producing a lipid-rich, impermeable layer around the cells

7

Stratum Lucidum

  • only in thick skin
  • thin, translucent layer of falttened eosiniphilic keratinocytes held together by desmosomes
  • Nuclei and organelles have been lost
  • cytoplasm has packed keratin filaments

8

9

Stratum corneum

  • 15-20 layers of squamous keratinized cell
  • fully keratinized cells (squames) are shed at epidermal surface as desmosomes and lipid rich cell envelopes break down

10

Eumelanins

  • Brown or black pigments produced by melanocyte
  • Red hair=pheomelanin

11

Depigmentation-Vitiligo

  • Acquired condition with loss or decreased activity of melanocytes (so no melanin)

12

Dermatofibroma

  • Neoplastic
  • Fibroblasts, dendritic cells

13

Dermatofibrosarcoma Proteburans

Fibroblasts

14

Hemangioma

Endothelial cells (vessels)

15

Hemangiosarcoma

Endothelial cells (vessels)