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Flashcards in Skin bio Deck (24):
1

sensory nerve dysfunction can cause what?

itch, dysesthetic pain/burning, hyperesthesia

2

After sensory nerve disfunction has occured, insensitivity to injury can be a consequence. what are some common?

neuropathic ulcers, trigeminal trophic syndrome

3

What is the role of the melanin?

protects against damage from UV radiation

4

Abnormal skin pigment is associated with what disease?

albinism

5

What is predisposed if immune surveillance is damaged?

infection, autoimmunity, cancer

6

If failure to regulate temp, what can result?

hypo- hyper thermia

7

If circulation is altered, what occurs?

infarction (emboli, vasculitis)

8

if communication function is damaged or altered, what is the result?

itching, insensitivity

9

If photoprotection is damaged, what could be the result?

cancer, photoaging

10

Which layers of skin fulfill the barrier and support roles?

epi: barrier => dermis:structural & nutritional

11

What are the 4 results of impairing the skin as a barrier fxn?

dehyrdration, infection, injury, inflammation

12

What disease is associated with the barrier fxn damage?

atopic dermatitis

13

What are 4 results of the skin's immune fxn damaged?

infection, cancer, inflam/autoimmune diseases, allergic rxns

14

What disease is associated with immune fxn disorder of epidermal adhesion due to autoantibodies of skin adhesion molecules?

autoimmune bullous diseases (erosions, blisters)=> bullous pemphigoid, pemphigus vulgaris

15

Disease associated with anti-desmosome antibodies

pemphigus vulgaris

16

disease associated with anti-hemidesmosome Abs

bullous pemphigoid

17

When repair of wounds fail, what is susceptible?

chronic skin ulcers, infection risks, mutations leading to cancer

18

Who is most prevalent to have XP?

children due to susceptibility of UV radiation causing them not to live to adults

19

What mutation is associated with hypohidrotic ectodermal dysplasia?

EDAR gene

20

What is the pathophys of the hypohidrotic ectodermal dysplasia?

EDAR mutatation leading to improper interaction of mesoderm and ectoderm development

21

How will a person present who has hypohidrotic ectodermal dysplasia?

unable to regulate temp (overheats) and abnormal hair follicles, sweat glands and teeth

22

Local thermoregulatory dysfxns can occur. What is a disease brought on by cold leading to episodic digitial ischemia?

Raynauds phenomenon

23

What is a disease that is associated with injured vessels that disrupt circulation leading to cutaneous necrosis/ulceration?

small vessel vasculitis

24

Anti-phospholipic Ab syndrome may present as what?

widespread cutaneous necrosis