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Flashcards in Vit D controversy Deck (20):
1

What is the right level of Vitamin D?

30 ng/mL

2

What is the relationship of UVR and Vit D?

cannot protect skin from damaging effects of UVR without decreasing formation of vit D

3

What is the active form of vitamin D?

1,25 (OH)2D3

4

When taking blood, what compound is Vitamin D measured?

25-hydroxy-vitamin D3 [25(OH)D3]

5

Who is at greatest risk for vitamin D deficiency?

elderly; northern latitudes, dark skin, elderly, obese

6

What are sources of Vit D?

sunlight; diet

7

What is the primary cause of epidemic low vitamin D worldwide?

decreased skin synthesis of vitamin D

8

What are causes of reduced skin synthesis of vitamin D?

season, latitude, skin pigment; aging; sunscreen; photprotection;

9

What are disease associated causes of vit D deficiency?

decreased bioavailability (malabsorption, obesity); heritable and acquired disorders; decreased synthesis (liver, renal)

10

What are key genes and pathways associated with vitamin D?

proliferation, differentiation, apoptosis, angiogenesis

11

What are the functions of vitamin D?

acts with PTH to maintain normal levels of calcium and phosphate

12

Systemically, what are the results of vitamin D?

increases intestinal absorption of Ca, PO4, Mg;
osteolytic effect on bone;
decreased renal clearance

13

What is the pathogenesis of Rickets?

Vitamin D deficiency leading to softening and weakening of bones associated with bending bones, Fxs

14

What is the Tx for rickets?

food fortification

15

What are adult skeletal manifestations of Vit D deficiency?

osteomalacia, osteopenia, osteoporosis, muscle weakness

16

What are the benefits of vitamin D supplementation?

daily oral supplementation of 800 IU; frail and elderly; enhances strength and decreases from fracture

17

What are the risk factors for individuals with 25 hydroxyvitamin D levels below 20ng/mL?

30-50% increase risk in colon cancer, prostate, breast cancer;
higher mortality from these cancers

18

What are the diseases more common at high latitudes?

CV disease; schizophrenia; depression; wheezing illnesses; autoimmune disease

19

If a person does not get adequate sun exposure, how can vit D be supplemented?

diet (supplements) => Vit D3 better and more effective at maintaining serum 25-hydroxyvitamin D levels

20

What is the avg vit D supplement that should be taken? Who should have more?

600 IU daily; elderly 800 IU daily