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Dermatology > Skin immunology > Flashcards

Skin immunology Flashcards

1
Q

How to keratinocyte cells aid the immune response?

A
  1. Anti microbial peptides
  2. Pathogen sensing
  3. Produce cytokines and chemokines
  4. Dead keratinocytes (corneocytes) make a tight barrier
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2
Q

What is the main resident skin immune cell?

A

Langerhans cell

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3
Q

In there more T cells in the blood or the skin?

A

Skin

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4
Q

What are CD4+ cells?

A

Helper T cells

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5
Q

What do CD4+ cells do?

A

Activate macrophages to destroy microorganisms. (TH1)

Help B cells to make antibodies (TH2)

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6
Q

What are CD8+ cells?

A

Cytotoxic T cells

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7
Q

What do CD8+ cells do?

A

Directly kill infected cells

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8
Q

Where are CD8+ cells mainly found?

A

The epidermis

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9
Q

Where are both CD8+ and CD4+ cells found?

A

The dermis

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10
Q

What type of T cells is there an increase in in psoriasis?

A

TH1, TH17

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11
Q

What type of T cells is there an increase in in atopic dermatitis?

A

TH2, TH17

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12
Q

What are neutrophils?

A

Circulating white blood cells which are attracted to tissues by chemokines

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13
Q

What are mast cells?

A

Effector cells of the IgE mediated response

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14
Q

What causes the release of histamine, TNF and tryptase from mast cells?

A

Binding of IgE

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15
Q

What is type 1 hypersensitivity?

A

IgE mediated reaction in which, on second exposure to the antigen, there is rapid degranulation of mast cells

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16
Q

What are the two stages in a Type 1 hypersensitivity response?

A
  1. Wheal and flare (rapid)

2. Cellular infiltration (later)

17
Q

What ire type 2 and 3 hypersensitivity reactions?

A

Antibody mediated, involved in autoimmunity and transplantation

18
Q

What is a type 4 hypersensitivity reaction?

A

Cell mediated, delayed type hypersensitivity.

19
Q

What type of hypersensitivity is allergic contact dermatitis?

A

Type 4

20
Q

Describe fizpatrick skin type 1

A

Fairest skin, always burns never tans

21
Q

Describe fitzpatrick skin type 6

A

darkest skin, never burns always tans

Dermatology (7 decks)

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