SLE

Question 1

Complications

Answer 1

Shrinking lung syndrome, Pleurisy, pleural effusion, pneumonitis, interstitial lung disease, pulmonary hypertension, and alveolar hemorrhage

Question 2

Shrinking lung syndrome

Answer 2

This syndrome is characterized by dyspnea, episodes of pleuritic chest pain, a progressive decrease in lung volume, and no evidence of interstitial fibrosis or significant pleural disease on chest CT. A review of the literature identified 77 patients with SLS and noted that 50 (65 percent) had pleuritic chest pain.
Conflicting results have been found concerning the underlying pathogenesis of this disorder. One possible mechanism is a myositis or myopathy affecting both diaphragms, resulting in elevation of the diaphragms and poor function. However, other reports have documented normal diaphragmatic muscle strength in patients with shrinking lung syndrome and restrictive lung disease. This
syndrome should be suspected in individuals with dyspnea, clear chest x-rays, and elevated diaphragms

Question 3

Antibody high specific for lupus

Answer 3

Anti-ds DNA, anti-smith

Question 4

RNP

Answer 4

myositis, less severe lupus

Question 5

Ro/SSA/SSB

Answer 5

Sjogren’s syndrome and neonatal lupus

Question 6

Ribosomal

Answer 6

neuropsychiatric manifestations

Question 7

Anti-histone

Answer 7

drug induced lupus, present in more than 95 percent of cases, in those taking procainamide, hydralazine, chlorpromazine, and quinidine
ds-DNA typically absence in above drugs. positive in anti-TNF induced drug lupus.

Question 8

Anti-phospholipid syndrome dermatological manifestation

Answer 8

livedo reticularis