Sleep-Wake DOs Flashcards

1
Q
  1. Which are Non-Benzo BZRAs?
  2. Which are Benzos Hypnotics BZRAs?
  • Eszopiclone, Zaleplon, Zolpidem
  • Estazolam, Flurazepam, Temazepam, Triazolam, Quazepam

BZRAs = Benzo Receptor Agonists

A
  1. Non-Benzo BZRAs = Eszopiclone, Zaleplon, Zolpidem
  2. Benzo BZRAs = Estazolam, Flurazepam, Temazepam, Triazolam, Quazepam
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2
Q

1st line Pharm Tx options for Insomnia

A
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3
Q

Which sleeping DO is Doxepin and Ramelton used for?

A

Insomnia

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4
Q

Wake-promoting chemicals

A
  • Orexin
  • Catecholamine
  • Histamine
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5
Q

Sleep-promoting chemicals

A
  • GABA
  • Serotonin
  • Adenosine
  • Melatonin
  • Prostaglandin
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6
Q

Hypersomnolence Tx

A
  1. Modafinil (Non-amphetamine CNS Stimulant)
  2. Armodafinil, Methylphenidate, Amphetamines
  3. Oxybate Salts (Xywav) -> DEEP SLEEP (REMS Program d/t date rape)
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7
Q
  • Mixed Oxybate salts (Xywav) is for _____
  • Sodium Oxybate (Xyrem) is ONLY for ______

Narcolepsy or Hypersomnia

A

Xywav = Hypersomnia
Xyrem = Narcolepsy ONLY

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8
Q

What is Cataplexy? What sleeping DO is this commonly seen in?

A

Sudden muscle weakness
Narcolepsy Type 1

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9
Q

In order to be Dx with CHRONIC Insomnia, Hypersomnolence, or Narcolepsy, you must have difficulty ____ nights a week for 3mo+

A

3

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10
Q

Drug class?
* Daridorexant, Lemborexant, Suvorexant

A

Dual Orexin Receptor Antagonists (DORAs)

Orexin keeps you awake. Antagonize Orexin -> SLEEPY
Used for insomnia

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11
Q

Drug Class?
Doxepin

A

Low-dose Histamine Receptor Antagonist

used for insomnia

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12
Q

Drug Class?
Ramelteon

A

Melatonin Receptor Agonist

used for insomnia

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13
Q

Narcolepsy Tx

A
  1. Modafinil, Armodafinil, Pitolisant, Solriamfetol
  2. Amphetamines, Methylphenidate

  • Severe sleepy & fail 1 med or Severe Cataplexy -> ADD or SWITCH Oxybates
  • Residual Cataplexy -> Effexor, Fluoxetine, Duloxetine, TCA
  • Milder Insomnia -> Short BZRA
  • Peds -> Traditional stimulants or Oxybates
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14
Q

Hyperventilation -> _____
Hypoventilation -> _______

CPAP or BIPAP?

A

Hyperventilation -> CPAP
Hypoventilaiton -> BiPAP

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15
Q

OSA Dx
* ____ Apneas/Hr + SS
* _____Apneas/Hr (regardless if SS or not)

A
  • 5 Apneas/Hr + SS
  • 15 Apneas/Hr
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16
Q

Central Sleep Apnea Dx
_____ Apneas/Hr

A

5

17
Q

Sleep related hypoventilaiton DO is episodes of _____Respiration with ____PaCO2

High or low?

A

LOW Respiration
HIGH PaCO2

18
Q

Tx for Sleep related hypoventilation DO

A

BiPAP

19
Q

Tx for Delayed Sleep Phase Type

A SPECIFIER for any sleeping DO

A
  • Bright light therapy
  • Chronotherapy
  • Melatonin
  • Ramelteon (melatonin receptor agonist)
20
Q

Tx for advanced sleep phase type DO

A

Bright light therapy
Melatonin

21
Q

Which sleeping DO?
Old person goes to bed early (6-9pm) and wakes up early (2-5am)

A

Advanced sleep phase type DO

  • Delayed sleep phase type = young person on their phone all night
  • Advanced sleep phase = seen in ADVANCED ages (old ppl)
22
Q

Which sleeping DO?
Sleep during day and awake at night

A

Irregular Sleep-wake DO

23
Q

Irregular Sleep-Wake DO Tx?

A
  • Bright light therapy
  • Structured physical/social activity
  • Melatonin
24
Q

Non-24Hr sleep-wake DO:
SS?
WU?

A
  • Sleep time jumps around
  • Sleep Diary
25
Q

Non-24Hr sleep-wake DO Tx:
- Blind?
- Sighted?

A
  • Blind -> Melatonin, Tasimelteon
  • Sighted -> Melatonin

Tasimelteon (Hetlioz) $$$ Melaotnin Agonist is Melatonin fails or pt doesnt want to try it

26
Q

Shift Work Sleeping DO Tx

A
  • Change work schedule
  • Sleep schedule
  • Zolpidem (Ambien) - Non-Benzo BZRA
  • Triazolam, Temazepam - Benzo BZRA

BZRA = Benzo Receptor Agonist

27
Q

Sleepwalking and nightmare DO are _____ Sleep DOs

NREM or REM?

A

NREM (Non-rapid eye mvmnt)

28
Q

Tx for SEVERE Sleepwalking
- #1 & #2
- Sexual Behaviors?
- Eating SS?

A
  • Melatonin
  • Benzos - Clonezapam (Klonopin)
  • Sexual -> SSRIs
  • Eating -> Topiramate (Anticonvulsant)
29
Q

Pharm Tx for Nightmare DO

A

Prazosin

30
Q

Tx for REM sleep DO

A
  • Melatonin
  • Clonazepam (Klonopin)
  • Donepezil (Aricept), Revastigmine (Exelon) - Ach Inhib
31
Q

Restless leg syndrome Dx: ss for ____mo+

A

3

32
Q

Restless leg syndrome Tx

A
33
Q

Restless Leg Tx if daytime ss

A

Carbidopa-Levodopa PRN (benzo)

34
Q

Restless leg Tx if CHRONIC

A
  1. GABA (Pregabalin, Gabapentin)
  2. Dopamine Agonist (Pramipexole, Ropinirole, Rotigotine)
35
Q

Restless leg Tx if REFRACTORY

A
  • Combo -> Dopamine agonist, GABA, Benzos
  • Low-dose Tramadol, Codeine
  • High-potency Oxycodone, Methadone