Slides 1 Flashcards
(123 cards)
1
Q
Afferent Pathways motor of sensory
A
Sensory - signal coming in
2
Q
Efferent Pathways are motor or sensory
A
Motor - signal is going out
3
Q
Hypoperfusion
A
Too little blood flow (ischemia)
Less that 20ml per 100g per minute
4
Q
At what point of blood loss does cell death occur
A
Below 10ml per 100g per minute
5
Q
What are the two major arteries that supply blood to the brain
A
- Common carotid arteries
2. Vertebral arteries
6
Q
Which is the most common place to loose blood in the brain?
A
Middle cerebral artery
7
Q
What are the two types of strokes
A
- Hemerrhagic stroke
2. Ischemic stroke
8
Q
Hemorrhage stroke
A
There is a blood leak into the brain
9
Q
Ischemic stroke
A
A clot (from brain or peripheri) stops blood supply to an area of the brain
10
Q
Which type of stroke is most common?
A
Ischemic stroke, they account for 80% of strokes
11
Q
What are the 2 types of ischemic strokes?
A
Thrombotic strokes = blood clot forms in an artery directly leading to the brain
Embolic Stroke = a clot forms somewhere else in the body and travels to the brain
12
Q
What is the difference between the core and the penumbra areas in an ischemic stroke?
A
Core area is there blood flow is below 10-25% and necrosis starts
Penumbra area is where there is less than 25-50% blood flow and eventually apoptosis will set in (can recover these regions)
13
Q
What differentiates neurons from other cells?
A
- Dendrites
- Axons
14
Q
What may neurons be classified by?
A
Shape
Neurotransmitters
Location
Connectivity
15
Q
What are macrocircuits
A
They are a group of neurons that project from one region of the brain to another
16
Q
What are microcircuits?
A
They are groups of neurons that project within a brain region
17
Q
What are the 4 main types of neurons?
A
Sensory
Motor
Principal
Inter
18
Q
Sensory neuron
A
Connected to receptors, they carry sensory information to the brain (afferent)
19
Q
Motor neurons
A
Responsible for the direct or indirect control of effector organs such as muscles and glands (efferent)
20
Q
Describe bipolar neurons
A
They are neurons one axon and one dendrite (that has multiple branches)
21
Q
Which neuron types are commonly bipolar?
A
Interneuron/principal neuron
22
Q
Describe a unipolar neuron
A
They have one main axon/dendrite and the soma protrudes off pf it
23
Q
What neurons are typically unipolar?
A
Sensory neurons
24
Q
Describe multipolar neurons
A
A soma that has multiple dendrites coming off of it and one main axon
25
What neurons are typically multipolar?
Motor neurons
26
How do interneurons and proncipal neurons differ from one another
Principal neurons are the neurons that connect everything together.
Interneurons exhibit inhibitory control over principal neurons/
27
Which has greater surface area, the soma or the dendrites?
Dendrites have a much bigger surface area
28
What gives dendrites such a big surface area?
The dendritic spines increase the size of dendrites surface area
29
What is a perkinjee cell?
A neuron with a large dendritic tree with a small soma
| A principal neuron but it releases GABA
30
What is the part of the post synaptic terminal that receives the NT from synapse called?
Post synaptic density
31
What are the 3 types of dendritic spines and what is the difference
1. Stubby
2. Thin
3. Mushroom
- -> They are essentially at different stages of the growth cycle
32
Thin dendritic spine
It is reaching out probing for an axon to make a connection with
33
Mushroom dendritic spine
It had a connection with an axon and it is the main excitatory input
34
Stubby dendritic spine
They do not have a connection yet but they will grow if they sense a possible connection
35
Axon Collaterals
A branch off the main axon
36
What significance does diameter size have for axons
Large diameter: less internal resistance so a faster signal flow
--> Also usually myelinated
Small diameter: more internal resistance that causes slower signal flow
37
Are organelles only in the soma?
No, they can travel up and down the axon on microtubules as needed
38
Difference between schwann cells and oligodendrocytes
```
Shwann:
- PNS
- Can heal
- single cell
myelinates a single
node
Oligodendrocyte:
- CNS
- Cannot heal
- single cell can
myelinate several
nodes and on
different axons
```
39
What are radial glial cells?
During development, radial glial cells are used as scaffolding for new neurons to travel up into the cortex
40
What happens to radial glial cells when the scaffolding is no longer needed?
They do not die, rather they turn into other glial cells
41
Do new neurons even travel back down the radial glial cells?
No, once they are in place they stay put
42
Progenitor Cells
***Fill in later***
43
Capacitance
The ability to store excess charges
44
What causes resistance in the membrane?
Ion channels (open vs closed)
45
What is required to keep the current flowing?
A source of energy
46
What does a closed system mean?
No energy is lost or grained
47
How are a capacitor and a battery similar?
They are both able to store energy and then use that energy to drive currents
48
What does a voltmeter do?
Measuring potential energy difference between two points
49
what is charge?
The source of the force between objects that can act at a distance
50
What properties of an atom make it a good conductor?
When its outer electrons have relatively weak bonds to their nuclei
51
What properties of an atom make a good insulator?
When its outer electrons are tightly bound to their nuclei
52
What is current?
It is the rate of flow of charge
| - Reported as the number of charges per unit time passing through a boundary
53
What is the standard unit for current?
Ampere (A) = one coulomb per second
54
Which direction does current usually flow?
From positive to negative == conventional current
55
How do negative charges flow in relation to positive charges?
In the opposite direction to the electric field
| == Opposite to conventional current
56
3 factors that affect resistance
- Material
- Cross-sectional area
- Temperature
57
What is the relationship between current and resistance?
Inversely related
| More resistance = less current
58
what is the relationship between current and voltage
They are directly proportional
59
OHM's law
The amount of current (I, measures in amps) flowing in a conductor is related to the potential different (V, volts) applied to it
60
Ohm's law equation
I = V/R
61
Does a stronger depolarization result in a higher amplitude action potential (amount of current flowing in)?
No, but it can result in a higher frequency of action potentials but with a fixed amplitude
62
What tool was used to measure the voltage in the giant axon in the squid?
The Oscilloscope
| - filled with salt water
63
Extracellular recording
Electrode is placed just outside the neuron of interest
| --> Looks at how populations of cells work together (in a live animal)
64
Intracellular recording
Electrode is inserted inside the neuron of interest
| --> in vitro (isolated from animal in a dish)
65
Patch clamp technique
the electrode is closely apposed to the neuron membrane, forming a tight seal with a patch of the membrane
- Isolates that part of the membrane and measures the activity of individual channels
66
What does the equilibrium potential depend on?
The concentrations of the respective ions (K+, Na+, Cl-) distributed on the inside and outside
67
The Nernst Equation
Equilibrium potential depends on the relative contribution of the particular ions inside and outside of the neural membrane
68
Where is the voltage difference the greatest?
Close to the membrane because the positive and negative ions on each side are attracted to each other and will migrate towards the membrane
69
Why does chloride more back and forth across the axon membrane?
Chloride moves into the axon to move down the concentration gradient, but it also flows back out of the cell because it is attracted to positive sodium ions
70
Resting membrane potential
-70mV
71
Particles on the outside of the neuron
Sodium (Na+)
| Chloride (Cl-)
72
Particles on the inside of the membrane
Potassium (K+)
| Large protein anions (A-)
73
Which ions can flow freely?
Chloride and potassium
74
What is the ratio of potassium ions inside to outside
20:1
75
Ratio of sodium ions inside to outside
10:1
76
What makes the inside of the neuron negative?
Large protein anions that cannot move outside of the cell and sodium channels are gated so they keep sodium out
77
Why don't chloride ions contribute much to the resting potential?
Because its equilibrium point (concentration gradient = voltage gradient) is the same as the membranes resting potential
78
Where do graded potentials most often occur?
On the dendrites
79
where do action potentials most often occur?
On the axon
80
What are graded potentials?
Small voltage fluctuations across the cell membrane
81
How do ions flow to create a hyperpolarization?
Influx of chloride
| Eflux of potassium
82
How do ions flow to create a depolarization?
Influx of sodium
83
Action potential
A large, brief reversal in polarity of an axon
84
Threshold of excitation voltage
~ -40 to -50mV
85
What is the cause of absolute refractory during the repolarization of the axon?
During the repolarization the voltage-insensitive sodium gate 2 are closed, so no matter how positively you drive the cell, they will not open
86
Nerve impulse
Propagation of an action potential on the membrane of an axon
87
What part of an action potential ensures that the impulse travels in only one direction?
the refractory periods
88
Conduction between nodes of ranvier
Saltatory conduction
89
Back propagation
Reverse movement of an action potential from the axon hillock into the dendrites
90
What is the potential function of back propagation?
May play a role in plastic changes in the neuron that underlie learning
91
Neuroepithelial cells can proliferate and generate what 2 things, and then differentiate into what?
Neuroblasts
Immature neurons
>> Then differentiate into radial glia
92
Most, but not all, astrocytes have what features in common?
Star-like
GFAP marker
Make contact with brain capillaries
93
Where are protoplasmic astrocytes located?
In the grey matter
94
What is the main function of protoplasmic astrocytes?
Their end-feet called perivascular end feet make contact with blood vessels as well as multiple contacts with neurons
95
Which astrocytes make up the blood brain barrier?
Protoplasmic astrocytes
96
Other than blood vessels and neurons, where to protoplasmic astrocytes make contact?
The pia matter
| = subpial end-feet
97
Where are fibrous astrocytes located?
In the white matter
98
What are the main points of contact for fibrous astrocytes?
At the nodes of Ranvier
| Also blood vessels (perivascular) and pia matter (sub-pial)
99
What is the purpose of fibrous astrocytes as the perinodes?
It cleans up the imbalance of ions in at the nodes of ranvier
> prevents ions from leaking in and out of axon
100
What are the 5 main roles of an astrocyte?
1. Control extracellular K+ homeostasis
2. Remove excess glutamate (protoplasmic)
3. Control local blood flow and provide neurons with metabolic support
4. Control synaptogensis and synaptic maintenance
5. (not main) Supply glutamate to main glutamatergic neurotransmission
101
How to oligodendrocytes and schwann cells form the myelin around axons?
By enwrapping their membrane several times around the axon
102
What role do schwann cells play with smaller axons if not providing myelin?
Encloses them to hold axons together
| >keeps them in place
103
Are there oligodendrocytes that do not myelinate?
Yes
| > do not know exact function
104
Where are non-myelinating oligodendrocytes found?
In the grey matter
105
What is the internodal region of an axon?
The area not covered by myelin --> node of ranvier
106
Is the internode (Node of Ranvier) empty?
No, fibrous astrocytes are there
107
How are microglia distributed through the CNS?
Relatively evenly
108
In what way to microglia combat pathogens?
Through phagocytosis
109
What functions to microglia have? (4)
1. Regulating cell death
2. Synapse pruning
3. Neurogenesis
4. Neuronal surveillance
110
What are the 2 phenotypes of microglia and what are their roles?
M1 - reactive >> will activate astrocytes to let t-cells in from the periphery to help with immune response
> Kill cells
M2 - repair cells, restrict BBB permeability
111
How can M1 microglial response be bad?
When M1 cells are triggered, they activate astrocytes to increase BBB permeability to let helper T-cells in to help with the immune response.
These T-cells can sometimes see oligodendrocytes as bas and attack them, destroying the myelin
112
What is the blood brain barrier?
A highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the CNS
113
What molecules are allowed to pass through the BBB?
```
Water
Some gasses
Lipid soluble molecules
Glucose
Amino acids
```
114
Cytoarchitectonics
One of the ways to parse the brain by staining it to reveal how neurons are "stacked" into layers
115
Area 41 and 42
Temporal lobe - hearing
116
Area 44 and 44
Broca's area for language
117
Area 1,2,3
Somatosentory
118
Area 17 and 18
Primary visual areas
119
What part of the brain to the common carotid arteries innervate?
Front and top
120
What part of the brain do the vertebral arteries innervate?
Middle and side
121
Does a principle cell synapse more with an interneuron than an interneuron synapses with a principle neuron, or vise versa?
Vis versa, an interneuron synapses more with a principle neuron than a principle neuron synapses with an interneuron
122
Glial cells interaction with the BBB (5)
1. Tight junctions
2. Structural support
3. Influence cell function
4. Channels for glucose and amino acids
5. Movement of sodium
123
Voltage
The measure of specific potential energy between two locations
