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Pharmacology > SNS > Flashcards

SNS Flashcards

1
Q

Name SNS agonists

A 
Phenylephrine/oxymetazoline
Alpha methyldopa/clonidine
Dopamine/Dobutamine
Salbutamol/Salmetarol
Amphetamine
Ephedrine
Cocaine
Adrenaline
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2
Q

MOA of phenylephrine

A

Selective a1 adrenergic receptor agonist

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3
Q

MOA of a-methyldopa

A

a2-adrenergic agonist

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4
Q

MOA of dopamine

A

B1-adrenergic agonist

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5
Q

MOA of salbutamol

A

B2-adrenergic agonist

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6
Q

Difference between amphetamine and ephedrine

A

Amphetamine has a potent release, whereas ephedrine has a weak release

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7
Q

MOA of amphetamine

A

Increases synaptic adrenaline, noradrenaline, dopamine and seratonin through re-uptake inhibition

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8
Q

MOA of ephedrine

A

Increases synaptic adrenaline, noradrenaline, dopamine and seratonin through re-uptake inhibition

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9
Q

MOA of cocaine

A

dopamine and noradrenaline re-uptake inhibitor

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10
Q

MOA of adrenaline

A

Bind to adrenergic receptors

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11
Q

Use of phenylephrine

A

Red eye allergy

Nasal congestion

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12
Q

Use of a-methyldopa

A

Hypertension

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13
Q

Use of dopamine

A

Acute heart failure/cardiogenic shock

Renal failure

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14
Q

Use of salbutamol

A

asthma
COPD
Premature labour

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15
Q

Use of amphetamine

A

ADHD
Narcolepsy
Reduce fatigue and appetite

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16
Q

Use of cocaine

A

Increases alertness, feelings of well-being and euphoria, energy and motor activity, feelings of competence and sexuality

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17
Q

Use of adrenaline

A

Anaphylaxis
Acute heart failure
Ventricular fibrillation
Cause vasodilation for local anaesthetic

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18
Q

Side effects of phenylephrine

A

Hypertension

Prostatic hyperplasia

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19
Q

Side effects of a-methyldopa

A 
Depression
Apathy
Anxiety
Fatigue
Reduced awareness and cognition
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20
Q

Side effects of dopamine

A

Hypertension
Angina
Arrhythmia
Tachycardia

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21
Q

Side effects of salbutamol

A 
Tremor
Anxiety
Headache
Muscle cramps
Dry mouth
Palpitations
Tachycardia
Arrhythmia
22
Q

Side effects of amphetamine

A

Hypertension

Increased cardiac output

23
Q

Side effects of ephedrine

A

Hypertension

Increased cardiac output

24
Q

Side effects of cocaine

A

Itchiness
Tachycardia
Hallucinations
Paranoid delusions

25
Q

Side effects of adrenaline

A

Increased cardiac output
Bronchodilation
Intestinal vasoconstriction

26
Q

Admin of phenylephrine

A

Topical
Oral
Nasal
Eye drops

27
Q

Admin of a-methyldopa

A

Oral

28
Q

Admin of dopamine

A

IV

29
Q

Admin of salbutamol

A

Inhalation

IV

30
Q

Admin of amphetamine

A 
Oral
IV
sublingual
Insufflation
Rectal
Vapourisation
31
Q

Admin of ephedrine

A 
Oral
IV
sublingual
Insufflation
Rectal
Vapourisation
32
Q

Admin of cocaine

A 
Oral
Insufflation
IV
Rectal
Inhalation
33
Q

Admin of adrenaline

A

Intramuscular

34
Q

Name SNS antagonists

A

Doxazosin/alfuzosin
Propranolol
Atenolol/Bisoprolol
Carvedilol

35
Q

MOA of doxazosin

A

Selective a1- adrenergic blocker

36
Q

MOA of propranolol

A

Non-selective beta blocker

37
Q

MOA of atenolol/bisoprolol

A

Selective b1-blocker (cardiac selective)

38
Q

MOA of carvedilol

A

Non-selective a1 and beta blocker

39
Q

Use of Doxazosin

A

Hypertension
Urine retention
Benign prostatic hypertrophy

40
Q

Use of propranolol

A 
Hypertension
Anxiety
Panic
Myocardial infarction
Angina pectoris
Migraine prophylaxis
41
Q

Use of Atenolol

A 
Hypertension
Angina pectoris
Post-myocardial infarction
Heart failure
Arrythmias
Migraine prophylaxis
Anxiety
42
Q

Use of carvedilol

A

Heart failure

43
Q

Side effects of doxazosin

A

Benign prostatic hyperplasia/hypertrophy

44
Q

Side effects of propranolol

A 
Nausea
Diarrhea
Bronchospasm
Dyspnea
Bradycardia
Hypotension
Heart failure
Fatigue
Dizziness
Hair loss
Hallucinations
Insomnia
Glucose & lipid metabolism changes
45
Q

Side effects of atenolol

A 
Indigestion
Constipation
Dry mouth
Dizziness
Cold extremities
Hair loss
Impotence
Depression
Confusion
Fatigue
46
Q

Side effects of carvedilol

A 
Hypoglycaemia
Bronchoconstriction
Low renin
Dizziness
Fatigue
Hypotension
Diarrhea
Astheniaa
Bradycardia
Weight gain
47
Q

Admin of doxazosin

A

Oral

48
Q

Admin of propanolol

A

Oral, anal, IV

49
Q

Admin of atenolol

A

Oral, IV

50
Q

Admin of carvedilol

A

Oral

Pharmacology (4 decks)

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