SNS Flashcards

(50 cards)

1
Q

Name SNS agonists

A
Phenylephrine/oxymetazoline
Alpha methyldopa/clonidine
Dopamine/Dobutamine
Salbutamol/Salmetarol
Amphetamine
Ephedrine
Cocaine
Adrenaline
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2
Q

MOA of phenylephrine

A

Selective a1 adrenergic receptor agonist

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3
Q

MOA of a-methyldopa

A

a2-adrenergic agonist

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4
Q

MOA of dopamine

A

B1-adrenergic agonist

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5
Q

MOA of salbutamol

A

B2-adrenergic agonist

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6
Q

Difference between amphetamine and ephedrine

A

Amphetamine has a potent release, whereas ephedrine has a weak release

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7
Q

MOA of amphetamine

A

Increases synaptic adrenaline, noradrenaline, dopamine and seratonin through re-uptake inhibition

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8
Q

MOA of ephedrine

A

Increases synaptic adrenaline, noradrenaline, dopamine and seratonin through re-uptake inhibition

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9
Q

MOA of cocaine

A

dopamine and noradrenaline re-uptake inhibitor

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10
Q

MOA of adrenaline

A

Bind to adrenergic receptors

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11
Q

Use of phenylephrine

A

Red eye allergy

Nasal congestion

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12
Q

Use of a-methyldopa

A

Hypertension

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13
Q

Use of dopamine

A

Acute heart failure/cardiogenic shock

Renal failure

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14
Q

Use of salbutamol

A

asthma
COPD
Premature labour

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15
Q

Use of amphetamine

A

ADHD
Narcolepsy
Reduce fatigue and appetite

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16
Q

Use of cocaine

A

Increases alertness, feelings of well-being and euphoria, energy and motor activity, feelings of competence and sexuality

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17
Q

Use of adrenaline

A

Anaphylaxis
Acute heart failure
Ventricular fibrillation
Cause vasodilation for local anaesthetic

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18
Q

Side effects of phenylephrine

A

Hypertension

Prostatic hyperplasia

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19
Q

Side effects of a-methyldopa

A
Depression
Apathy
Anxiety
Fatigue
Reduced awareness and cognition
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20
Q

Side effects of dopamine

A

Hypertension
Angina
Arrhythmia
Tachycardia

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21
Q

Side effects of salbutamol

A
Tremor
Anxiety
Headache
Muscle cramps
Dry mouth
Palpitations
Tachycardia
Arrhythmia
22
Q

Side effects of amphetamine

A

Hypertension

Increased cardiac output

23
Q

Side effects of ephedrine

A

Hypertension

Increased cardiac output

24
Q

Side effects of cocaine

A

Itchiness
Tachycardia
Hallucinations
Paranoid delusions

25
Side effects of adrenaline
Increased cardiac output Bronchodilation Intestinal vasoconstriction
26
Admin of phenylephrine
Topical Oral Nasal Eye drops
27
Admin of a-methyldopa
Oral
28
Admin of dopamine
IV
29
Admin of salbutamol
Inhalation | IV
30
Admin of amphetamine
``` Oral IV sublingual Insufflation Rectal Vapourisation ```
31
Admin of ephedrine
``` Oral IV sublingual Insufflation Rectal Vapourisation ```
32
Admin of cocaine
``` Oral Insufflation IV Rectal Inhalation ```
33
Admin of adrenaline
Intramuscular
34
Name SNS antagonists
Doxazosin/alfuzosin Propranolol Atenolol/Bisoprolol Carvedilol
35
MOA of doxazosin
Selective a1- adrenergic blocker
36
MOA of propranolol
Non-selective beta blocker
37
MOA of atenolol/bisoprolol
Selective b1-blocker (cardiac selective)
38
MOA of carvedilol
Non-selective a1 and beta blocker
39
Use of Doxazosin
Hypertension Urine retention Benign prostatic hypertrophy
40
Use of propranolol
``` Hypertension Anxiety Panic Myocardial infarction Angina pectoris Migraine prophylaxis ```
41
Use of Atenolol
``` Hypertension Angina pectoris Post-myocardial infarction Heart failure Arrythmias Migraine prophylaxis Anxiety ```
42
Use of carvedilol
Heart failure
43
Side effects of doxazosin
Benign prostatic hyperplasia/hypertrophy
44
Side effects of propranolol
``` Nausea Diarrhea Bronchospasm Dyspnea Bradycardia Hypotension Heart failure Fatigue Dizziness Hair loss Hallucinations Insomnia Glucose & lipid metabolism changes ```
45
Side effects of atenolol
``` Indigestion Constipation Dry mouth Dizziness Cold extremities Hair loss Impotence Depression Confusion Fatigue ```
46
Side effects of carvedilol
``` Hypoglycaemia Bronchoconstriction Low renin Dizziness Fatigue Hypotension Diarrhea Astheniaa Bradycardia Weight gain ```
47
Admin of doxazosin
Oral
48
Admin of propanolol
Oral, anal, IV
49
Admin of atenolol
Oral, IV
50
Admin of carvedilol
Oral