Somatostatin Analogs

Question 1

What drugs are in the Somatostatin Analogs class?

Answer 1

Drugs in this class are:
- Octreotide
- Lanreotide

Question 2

What is the brand name of Octreotide?

Answer 2

The brand name of this generic drug is:
- SandoSTATIN/LAR Depot

Question 3

What is the brand name of Lanreotide?

Answer 3

The brand name of this generic drug is:
- Somatuline Depot

Question 4

What is the generic of name of SandoSTATIN?

Answer 4

The generic name of this brand name drug is:
- Octreotide

Question 5

What is the generic of name of Somatuline Depot?

Answer 5

The generic name of this brand name drug is:
- Lanreotide

Question 6

What are the main/common indications of the Somatostatin Analogs class?

Answer 6

The main/common indications of this drug class are:
- Carcinoid Crisis/Syndrome
- Neuroendocrine Tumors

Question 7

What is the class and MOA of Octreotide?

Answer 7

This drug in the following class:
- Somatostatin Analogs

This drug’s MOA is as follows:
- Mimics natural somatostatin by inhibiting serotonin release and the secretion of gastrin, VIP, insulin, glucagon, secretin, motilin, and pancreatic polypeptide
- Control symptoms that result from release of peptides and neuroamines from neuroendocrine tumors and help control the disease itself

Question 8

What is the class and MOA of Lanreotide?

Answer 8

This drug in the following class:
- Somatostatin Analogs

This drug’s MOA is as follows:
- Mimics natural somatostatin by inhibiting serotonin release and the secretion of gastrin, VIP, insulin, glucagon, secretin, motilin, and pancreatic polypeptide
- Control symptoms that result from release of peptides and neuroamines from neuroendocrine tumors and help control the disease itself

Question 9

Describe the half-life of Octreotide.

Answer 9

The half-life of this drug is described as follows:
- Duration of action:
- SubQ: 6 to 12 hours
- IM (LAR depot suspension): Following a single injection, a steady concentration is achieved within 2 to 3 weeks and maintained for an additional 2 to 3 weeks; steady-state levels are achieved after 3 injections administered at 4-week intervals.

Question 10

What are the clinical pearls of the Somatostatin Analogs class?

Answer 10

The clinical pearls of this drug class are as follows:
- Carcinoid syndrome primary occurs in patients with well differentiated metastatic neuroendocrine tumors.
- Signs and symptoms include diarrhea and flushing.
- Serotonin is thought to be the most important factor in the etiology of carcinoid syndrome diarrhea.
- Long acting somatostatin analogs are highly active for the control of flushing/diarrhea as well as long term disease control.
- Short acting analogs can be used for immediate effect in patients with uncontrolled carcinoid syndrome.
- Short-acting octreotide can also be added to octreotide long-acting release for the treatment of breakthrough symptoms.

Question 11

What are the notable/common ADRs of the Somatostatin Analogs class?

Answer 11

The notable/common ADRs of this drug class are:
- Bradycardia
- Edema
- Hyperglycemia