Spatial normalization

Question 1

Intersubject registration

Answer 1

The process of spatial normalisation where indivuals data is transformed into a standardised space to allow data to be integrated across individuals who are anatomically variable

Question 2

Atlas

Answer 2

An atlas provides a guide to the location of anatomical structures in a co-ordinate space

Question 3

Templates

Answer 3

A template is a representative of an image that provides a target to which individual images can be aligned.

Templates can be based from Talariach (a single 60 year old post mortem female brain) or MNI - the average of 152 scans from healthy young adults

Talariach requires land-mark based registration, whereas MNI is automated.

A structural image is normally taken and co-registered with functional images (incase individual has moved). Structural image is then normalised to the template and these parameters are applied to the functional data

Question 4

where is the 0, 0, 0 co-ordinates of the MNI atlas?

Answer 4

The anterior commisure