Special Notes

Question 1

Diuretics ineffective with renal impairment

Answer 1

Thiazides (except Metolazone)

Question 2

Diuretics effective with renal impairment

Answer 2

Loop diuretics

Question 3

Diuretic that reduces cardiac remodelling in HF

Answer 3

Spironolactone

Question 4

Selective B blockers

Answer 4

Metoprolol, atenolol

Question 5

Alpha, beta blockers

Answer 5

Labetalol, carvedilol

Question 6

Used for hypertensive pregnants

Answer 6

Alpha methyldopa

Question 7

Useful in hypertensive patients with renal impairment

Answer 7

Alpha 2 agonists

Question 8

IV antihypertensive that doesn’t reduce renal perfusion and is useful in patients with renal insufficiency

Answer 8

Fenoldopam

Question 9

Recommended to be used immediately after MI

Answer 9

ACEI

Question 10

Used for left ventricular systolic dysfunction and not for diastolic or right sided HF

Answer 10

Digoxin

Question 11

Their abrupt discontinuation can lead to rebound hypertension and angina

Answer 11

BB, clonidine

Question 12

Diuretics used in ttt of diabetes insipidus

Answer 12

Thiazides

Question 13

Can be used to treat hypercalciuria (Ca oxalate stones in urine)

Answer 13

Thiazides

Question 14

Ineffective diuretic in a patient wz Addison disease

Answer 14

Spironolactone

Question 15

Diuretics used for glaucoma and mountain sickness

Answer 15

Carbonic anhydrase inhibitors e.g. Acetazolamide

Question 16

Second generation antipsychotic that is a partial agonist of D2 receptors

Answer 16

Aripiprazole

Question 17

Antipsychotic that has antiemetic and antihistaminic action and used for motion sickness and pruritis

Answer 17

Promethazine

Question 18

Antipsychotic used for chemotherapy- induced nausea

Answer 18

Haloperidol

Question 19

Antipsychotic used for ttt of motor and phonic tics

Answer 19

Pimozide

Question 20

Antipsychotic used for Bipolar disorder and depression

Answer 20

Aripiprazole

Question 21

Antipsychotic with profound sedative effect

Answer 21

Chlorpromazine

Question 22

Antiepileptic used only in absence seizures

Answer 22

Ethosuximide

Question 23

Antiepileptic used for partial seizures, tonic- clonic seizures, trigeminal neuralgia and bipolar disorder

Answer 23

Carbamazepine

Question 24

Antiepileptic used for partial seizures and ttt of postherpetic neuralgia

Answer 24

Gabapentin

Pregabalin» also for neuropathic pain, diabetic neuropathy, fibromyalgia

Question 25

Antiepileptic used for partial, generalized, absence seizures and bipolar disorder

Answer 25

Lamotrigine

Question 26

Antiepileptic that is used in ttt of status epilepticus

Answer 26

IV Phenobarbital

Question 27

The use of this antiepileptic requires the use of additional birth control method

Answer 27

Topiramate

Question 28

Antiepileptic with broad spectrum activity against seizures and with teratogenic effect

Answer 28

Valproic acid

Question 29

LABA that is not used for acute asthma

Answer 29

Salmeterol, formoterol

Question 30

Nicotine withdrawal symptoms

Answer 30

Craving, nervous, difficulty concentrating, anxiety, increase appetite (wt gain)

Question 31

Nicotine overdose symptoms

Answer 31

Palpitation, difficulty breathing, N V D

Question 32

Method of smoking cessation in which you have to stop smoking completely

Answer 32

Nicotine based: nicotine patch or gum

Question 33

Method of smoking cessation in which you can smoke for the first 2 weeks of treatment

Answer 33

Non nicotine base: bupropion (Zyban)

Question 34

Nicotine patch storage conditions

Answer 34

Room temp.

Question 35

Dosage forms of NRT

Answer 35

Inhalers, spray, gum, patch, lozenges

Question 36

Can Bupropion be taken with NRT ?

Answer 36

Yes, with or without NRT

Question 37

An exam used to assess cognitive impairment

Answer 37

Minimental scale exam (MMSE)

Question 38

A pseudoirreversible AchEI

Answer 38

Rivastigmine

Question 39

A competitive AchEI

Answer 39

Galantamine

Question 40

Phenytoin dosage forms

Answer 40

Suspension, chewable tablet, capsule, IV

Question 41

Antiepileptics that don't interact with oral contraceptives

Answer 41

Gabapentin, valproic acid

Question 42

Antidepressants used for management of chronic pain, neuropathic pain and diabetic peripheral neuropathy

Answer 42

SNRI | TCA (lesser extent)

Question 43

SNRI that should not be used in hepatic insufficiency or end stage renal disease

Answer 43

Duloxetine

Question 44

Their abrupt stop may precipitate discontinuation syndrome

Answer 44

``` SNRI SSRI (except fluoxetine as it has v. long half life) ```

Question 45

A drug that is used to overcome craving and attenuate the withdrawal symptoms of nicotine

Answer 45

Bupropion

Question 46

Antidepressant with highest sedating properties

Answer 46

Mirtazapine

Question 47

Insomnia self care

Answer 47

Avoid exercise before bedtime.

Question 48

Drugs used for weight loss therapy

Answer 48

Orlistat, Sibutramine, Bupropion, Topiramate

Question 49

Drugs gives loss of appetite

Answer 49

Metformin, amiodarone, CNS stimulants (amphetamine & methylphenidate)

Question 50

Drugs increase appetite

Answer 50

TCA, corticosteroids, oral contraceptive, sulfonylurea

Question 51

Drugs causes weight gain

Answer 51

TCA, sulfonylurea, insulin, MAOI, antipsychotic 2nd generation, meglitinides

Question 52

All insulin are clear solution except ?

Answer 52

Intermediate insulin NPH | Humulin N, Novolin N

Question 53

Types of insulin to be taken as IV

Answer 53

Ultra rapid & rapid insulin

Question 54

Produce earlier insulin release than the other Sulfonylureas

Answer 54

Gliclazide (Diamicron)

Question 55

Sulfonylurea that needs dose adjustment in renal impairment

Answer 55

Chlorpropamide, Glyburide

Question 56

Sulfonylurea with the lowest risk of cardiovascular events & high hypoglycemia

Answer 56

Glyburide (Diabeta)

Question 57

Sulfonylurea with the lowest risk of hypoglycemia

Answer 57

Glimepiride (Amaryl)

Question 58

Long acting 3rd generation Sulfonylurea

Answer 58

Glimepiride

Question 59

Oral antidiabetic drug that is good for obese patient & no hypoglycemia

Answer 59

Metformin

Question 60

B2 agonists that act as tocolytic agents

Answer 60

Isoxuprine, ritodrine

Question 61

Type of insulin that is not mixed with other insulins

Answer 61

Long acting | Glargine & Detemir

Question 62

Oral hypoglycemic that is safe in pregnancy

Answer 62

Glyburide

Question 63

Oral hypoglycemic drug that is used in polycystic ovarian syndrome

Answer 63

Metformin and thiazolidinediones

Question 64

Can cause resumption of ovulation in post menopausal women

Answer 64

Thiazolidinediones

Question 65

If hypoglycemia occurs with patient taking Sulfonylurea & acarbose, what will be given to him?

Answer 65

Glucose not sucrose

Question 66

Oral hypoglycemic drugs can be taken with or without food

Answer 66

DPP-4inhibitors | Thiazolidinediones (PPAR-y agonist)

Question 67

Used in the treatment of prostatic cancer, endometriosis, precocious puberty

Answer 67

GnRH analogues: goserelin, nafarelin, histrelin | Their continuos administration results in the suppression of gonadal hormones

Question 68

Used for ttt of hyperprolactinemea, macroprolactinomas, pituitary microadenoma

Answer 68

D2 receptor agonists: bromocriptine, cabergoline

Question 69

Can cause suppression of TSH secretion

Answer 69

Dopamine, GH, glucocorticoids

Question 70

Persistent asthma

Answer 70

Inhaled corticosteroids

Question 71

Patients counseling for use of MDI (metered dose inhalers) and DPI (dry powder inhalers)

Answer 71

MDI: breath in slowly and deeply just before the activation of the inhaler DPI: breath in quickly and deeply after the activation of the inhaler For both: mouth rinsing after the dose to reduce the risk of systemic side effects

Question 72

A corticosteroid that has an antiemetic action

Answer 72

Dexamethasone

Question 73

Oral contraceptive used for severe acne

Answer 73

Diane 35 (cyproterone/ EE)