Specific Proteins 2 Flashcards by Asherah Undug

Q

Main components of globulins:

A

Pre-albumin
Albumin
A1 globulin
A2 globulin 
B globulin
Gamma globulin

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Q

Identify the specific proteins of the fractions:

Pre- albumin

A

Prealbumin

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Q

Identify the specific proteins of the fractions:

Albumin

A

Albumin

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Q

Identify the specific proteins of the fractions:

A1 globulin

A

A1 anti trypsin 
A1 acid glycoprotein 
A1 lipoprotein
Transcortin
AFP TBG

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Q

Identify the specific proteins of the fractions:

A2 globulin

A

Haptoglobulin
A2 macroglobulin
HDL
Ceruloplasmin

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Q

Identify the specific proteins of the fractions:

B globulin

A

B1 and B2 transferrin
LDL
C3-C4
Transferrin 
Hemopexin

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Q

Identify the specific proteins of the fractions:

Gamma globulin

A

Ig
Fibrinogen
CRP

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Q

Types of plasma proteins:

A

Albumin
Globulin
Fibrinogen

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Q

Which specific protein transport the ff:

FA, bilirubin, Ca

A

Albumin

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Q

Which specific protein transport the ff:

Iron

A

Transferrin

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Q

Which specific protein transport the ff:

Copper

A

Ceruplasmin

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Q

Which specific protein transport the ff:

Cortisol, corticosterone

A

Transcortin

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Q

Which specific protein transport the ff:

Lipids

A

Lipoprotein

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Q

Which specific protein transport the ff:

Free hemoglobin

A

Haptoglobin

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Q

Which specific protein transport the ff:

Thyroxine

A

TGB

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Q

Which specific protein transport the ff:

Retinol

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A

Retinol binding protein

Q

The most important in regulation of colloidal osmotic/ oncotic pressure

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A

Albumin

Q

Combines with elastase and trypsin to protect the hydrolytic damage of tissues and lungs

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A

A1 antitrypsin

Q

Breakdown thrombin and dissolves blood clot

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A

Plasmin

Q

Positive acute phase reactants:

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A

CRP - 1000 fold
A1 anti trypsin
Fibrinogen
Haptoglobin
C3, C4
Serum amyloid

Q

Negative acute phase reactants

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A

Albumin
Transferrin 
Antithrombin
Transcortin
RBP

Q

The fraction that migrates in a position faster than albumin towards the anode

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A

Pre albumin

Q

Characteristics of prealbumin:

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A

Tetramere structure - MW 62,000 Da
2nd most predominant protein in CSF
One of the smaller serum proteins
Rich in tryptophan
Beta pleated sheet conformation
Short half life - 2 days

Q

Functions of prealbumin:

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A

Carrier protein for thyroxine - thyroxine binding prealbumin (TBPA) or transthyretin (TTR)

Significant role in vitamin A metabolism - it holds the rretinol binding protein (RBP) in the plasma to prevent it from rapid removal from the circulation by filtration through the kidneys

Portion of prealbumin is the source of beta fibrillar amyloid component in ____________________

Type 1 familial amyloidotic polyneuropathy

Synthetic rate of prealbumin is sensitive to:

Adequate nutrition | Alterations in hepatic function

Better early indicator of change in nutritional status and an important factor for planning patient management

Prealbumin Low levels is associated with greater risks of mortality and hospitalization

True prealbumin is best quantified by:

Nephelometry

A protein band frequently appears in the prealbumin postion in pts with:

Heparin therapy

Absence of albumin:

Analbuminemia

Presence of 2 bands in the albumin region:

Bisalbuminemia

Decrease level of albumin, typical of nephritic syndrome

Hypoalbuminemia

Characteristics of albumin:

Most abundant protein in normal plasma Serves as mobile repository of amino acids General transport or carrier protein Consists of 585 AA

Depression in albumin levels result to serious imbalance of intravascular oncotic pressure manifested clinically by;

Peripheral edema

Has regions of homology with serum albumin

Alpha fetoprotein