SPIROCHETES Flashcards
SPIROCHETES motility
corkscrew
Organisms that can’t be visualize in brightfield microscopy
SPIROCHETES
SPIROCHETES are Motile because they produce
axial fibrils (flagella)
disease of blood vessels; sexually transmitted disease
Syphilis
turning threads
Treponema
Non-culturable on artificial media
Treponema pallidum
Treponema pallidum treatment
Penicillin - Jarisch-Herxheimer reaction
transplacental transmission of syphilis
Congenital Syphillis
Congenital Syphilis
○ Early stage is like the second stage or _______
○ Late stage is the latent stage or _______
condylomata
deadly
seen in children who had congenital syphilis (3)
Hutchinson triad
■ deafness
■ blindness
■ notched or pegged teeth
Clinical Infection of Syphilis
Primary Stage. (4)
Hard Chancre
- unitarian?
- genitalia dry lesions
- not painful
Clinical Infection of Syphilis
Secondary Stage (5)
Condylomata lata
- wart-like
- genitalia
- 6-8 weeks
- after dry lesions (hard chancre)
Clinical Infection of Syphilis
Latent Stage (3)
Asymptomatic
- hidden
- serological stage
Clinical Infection of Syphilis
Tertiary Stage (3)
Gumma’s
- deep organs
- neuro/cardiac syphilis
Syphilis Serological Tests
Non-Treponemal
Treponemal
sero test that is not specific for syphilis
Non-Treponemal
specific test for syphilis
Treponema
Non-Treponemal tests (3)
● VDRL
● RPR
● TRUST
Treponemal tests (5)
● TPI
● TPHA
● MHA-TP
● FTA-ABS
● RPCF
heated serum (waterbath); microscopic
VDRL
RPR (4)
commonly used today;
neurosyphilis (CSF);
modified version of VDRL;
macroscopic
most specific test for syphilis
FTA-ABS
uses nonvirulent treponeme; nonreactive for late stage of syphilis
RPCF
Yaw or Frambesia
T. pallidum subsp. pertenue
