St Adrenals and Paragangliomas Flashcards Preview

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Flashcards in St Adrenals and Paragangliomas Deck (23)
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1

Fetal adrenal with primitive sympathetic cells forming neuroblastic nodules

2

Newborn adrenal with focal cytomegaly of fetal cortex

3

Newborn adrenal  of Beckwith-Wiedemann syndrome with widespread cytomegaly

4

Atrophic adrenal gland:

  • fibrotic capsule and cortical layer is atrophic but medulla unaffected.

DDx adrenal hypofuntion:

  • atrophic:autoimmune (lymphocytes and plasma cells, abs sto P450 enzyme), Type I polyglandular autoimmune sydrnome (APECED, AR), Type II polyglandular autoimmune syndrome (AD), previous Waterhouse-Friderichsen (fibrosis), exogenous corticosteroid, Cushing syndrome
  • necrotic: CMV
  • replacement: TB (caseous), fungus (caseous), Amyloidosis, tumour, Waterhouse-Friderichsen (blood), anticoagulatn tx (blood)

5

Adrenocortical hyperplasia

  • vacuolated fasciculata 

6

Primary hyperaldosteronism

  • Hyperplasia of zona glomerulosa

7

Primary pigmented nodular adrenocortical disease - microadenomatous hyperplasia:

  • Nodules of large, granular eosinophilic cells with enlargec hyperchromatic nuclei with prominent nucleoli
  • filled with lipochrome
  • associated with Carney complex (PRKAR1A)

8

Pigmented (black) adrenocortical adenoma

  • associated with Cushing syndrome
  • compact cells with lipochrome pigment

9

Adrenocortical adenoma with stromal fibrosis

  • associated with Cushing syndrome

10

Adrenocortical adenoma, myelolipomatous change

  • Associated with Cushing syndrome

11

Adrenocortical carcinoma

  • areas of necrosis

12

Adrenocortical carcinoma

  • marked nuclear pleomorphism
  • intranuclear pseudoinclusions

13

Adrenal cyst, endothelial type (+ Factor VIII)

  • other types: epithelial, parasitic, endothelial and psuedocysts

14

Adrenal myelolipoma

  • hematopoeitic tissue scattered among fat

15

Metastatic pulmonary adenocarcinoma

16

Adrenal gland with metastatic bronchogenic adenocarcinoma, FNA

17

Adrenocortical hemangioma

18

Adenomatoid tumour

  • glands and tubules
  • +: calretinin and CK

19

Ganglioneuroma

20

Pheochromocytoma

21

Pheochromocytoma

  • +: Chromogranin A

 

22

Diffuse hyperplasia of adrenal medulla

  • anisonucleosis of cells expected

23

Pheochromocytoma, S100+ sustentacular cells