Statins (HMG-CoA reductase inhibitors)

Question 1

Drugs

Answer 1

Atorvastatin (Lipitor)
Rosuvastatin Crestor)
Simvastatin (Zocor)

Question 2

MOA

Answer 2

Inhibiting HMG-CoA reductase results in reduced LDL produced in liver

Lower LDL production increases LDL receptor production&raquo_space;> more LDL removed from the blood

Question 3

Indications

Answer 3

Hyperlipidemia
Prevention of CVD

First line for hyperlipidemia

Question 4

SE/AE

Answer 4

Hepatotoxicity
Myopathy, which can progress to rhabdomyolysis

Question 5

Contraindications

Answer 5

Pregnancy
Grapefruit juice (inhibits metabolism of statins)
Severe liver disease

Question 6

Administration

Answer 6

Drugs are all given orally
Preferred to be taken in evening (cholesterol synthesis occurs at night)
Dosages are low, medium, high
LDL reduction by ~30%, ~30-50%, and ~50% respectively