Stimulants

Question 1

Tx of psychotic state brought on by stimulant toxicity

Answer 1

first generation antipsychotic like haloperidol

Question 2

Doing this makes stimulants more excretable in the urine

Answer 2

acidifying the urine (ammonium chloride)

Question 3

Dependence and stimulants

Answer 3

primarily psychological

biological dependence is hotly debated, may cause depression Sx

Question 4

2 appropriate medical uses of stimulants

Answer 4

ADHD

narcolepsy

Question 5

Which has a longer half-life: cocaine or methamphetamine?

Answer 5

cocaine

Question 6

Which is more potent: cocaine or methamphetamine?

Answer 6

cocaine

Question 7

How does cocaine cause motor Sx?

Answer 7

blocking NE reuptake

Question 8

How does cocaine cause euphoria?

Answer 8

blocking DA reuptake

Question 9

Is cocaine dependence psychological or physical?

Answer 9

primarily psychological

Question 10

Biggest worry with stimulant overdose

Answer 10

cardiac arrythmias

Question 11

What is MDMA?

Answer 11

ecstacy–Molly is purer form

Question 12

MDMA inhibits the reuptake and stimulates the release of

Answer 12

dopamine
NE
Epi

Question 13

This drug is used to make PTSD patients more empathetic (or is being tested anyways)

Answer 13

MDMA

Question 14

This directly stimulates 5HT2-1A receptors

Answer 14

MDMA

Question 15

Why does MDMA also affect mood?

Answer 15

stimulates seratonin release and blocks reuptake

Question 16

What is MDMA derived from?

Answer 16

amphetamines

Question 17

Bath salts

Answer 17

completely synthetic amphetamine-like substances

Question 18

Biggest example of xanthine

Answer 18

caffeine + theophylline

Question 19

How do xanthines affect the heart?

Answer 19

direct stimulation

increases stroke volume and rate = increased CO

Question 20

What effect do xanthines have an skeletal muscle?

Answer 20

increase work capacity

Question 21

What is the mechanism of action of xanthines?

Answer 21

unknown

may cause translation of intracellular Ca2+

Question 22

How much caffeine is toxic?

Answer 22

10 g

Question 23

Therapeutic use of caffeine

Answer 23

migraines

Question 24

How does caffeine affect respirations?

Answer 24

affects medullary center, increases RR

Question 25

How do large does of caffeine affect the spinal cord?

Answer 25

hyperreflexia

Question 26

Modafininil and armodafinil MOA

Answer 26

increase DA in striatum and nucleus accumbens

Question 27

Modafininil and armodafinil therapeutic uses

Answer 27

narcolpesy shift work sleep disorder excesssive daytime sleepiness for sleep apnea