Stroke Flashcards

(48 cards)

1
Q

2 main types of stroke

A

ischaemic 85% (TIA if <24hr, ischaemic stroke if >24hr)

haemorrhagic 15%

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2
Q

subtypes of ischaemic stroke?

A

thrombotic

embolic (AF big risk factor)

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3
Q

subtypes of haemorrhagic stroke?

A

intracerebral haemorrhage

SAH

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4
Q

risk factors for
1) ischaemic
2) haemorrhagic
stroke

A

1) cardiovascular: age, hypertension, smoking, hyperlipidaemia, DM
2) age, hypertension, AVM, anticoagulation therapy

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5
Q

what is stroke (WHO defintion)

A

rapidly developing clinical signs of focal (at times global) disturbance of cerebral function, lasting more than 24 hours or leading to death with no apparent cause other than that of vascular origin

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6
Q

symptoms of a cerebral hemisphere infarct?

A

contralateral hemiplegia (flaccid then spastic)
contralateral sensory loss
homonymous hemianopia
dysphasia

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7
Q

symptoms of brainstem infarction?

A

may have more severe symptoms including quadriplegia and lock-in syndrome

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8
Q

what are lacunar infarcts?

A

small infarcts around the basal ganglia, internal capsule, thalamus and pons

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9
Q

symptoms of lacunar infarcts?

A

pure motor, pure sensory, mixed motor and sensory signs or ataxia

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10
Q

what 3 criteria is the oxford stroke classification system based on?

A

1) hemiplegia or hemi-sensory loss in face, arm and leg
2) homonymous hemianopia
3) high cognitive deficit e.g. aphasia

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11
Q

what 3 criteria is the oxford stroke classification system based on?

A

1) unilateral hemiparesis and/or hemisensory loss of the face, arm & leg
2) homonymous hemianopia
3) higher cognitive deficit e.g. dyphasia

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12
Q

Total anterior circulation infacts (TACI)

1) involves which cerebral arteries
2) which oxford stroke classification criteria are present?

A

1) middle and anterior

2) all 3

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13
Q

Partial anterior circulation infacts (PACI)

1) involves which cerebral arteries
2) which oxford stroke classification criteria are present?

A

1) small arteries of anterior circulation e.g. upper or lower division of MCA
2) just 2

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14
Q

.

A

.

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15
Q

Lacunar infarcts (LACI)

1) involves which cerebral arteries
2) presents how?

A

1) perforating arteries around internal capsule, thalamus and basal ganglia
2) 1 of:
- unilateral weakness (and/or sensory deficit) of face and arm, arm and leg or all three.
- pure sensory stroke
- ataxic hemiparesis

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16
Q

Posterior circulation infarcts (POCI)

1) involves which cerebral arteries
2) which oxford stroke classification criteria are present?

A

1) vertebrobasilar arteries
2) 1 of:
- cerebellar or brainstem syndromes
- LOC
- Isolated homonymous hemianopia

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17
Q

Whilst symptoms alone cannot be used to differentiate haemorrhagic from ischaemic strokes, patients who’ve suffered haemorrhages are more likely to have:

A

decreased LOC

HA, N&V, seizure

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18
Q

why is neuroimaging urgently indicated in stroke?

A

to classify as either ischaemic or haemorrhagic and thereby determine whether thrombolysis can be done

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19
Q

what is the criteria for offering thrombolysis in stroke?

A

must administer within 4.5hrs of onset of symptoms

haemorrhage has been definitively excluded (i.e. imaging)

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20
Q

once haemorrhagic stroke has been excluded patients should be given what medication?

A

300mg aspirin

21
Q

immediate management of TIA?

A

aspirin 300mg (unless contraindicated)

22
Q

referral pathway

1) if patient has had suspected TIA in last 7 days
2) if patient has had suspected ITA more than 1 week previously

A

1) urgent assessment within 24hr by stroke specialist

2) urgent specialist assessment within 7 days

23
Q

T/F: the vast majority of patients with haemorrhagic stroke will undergo surgical intervention

A

false - most not suitable for surgical intervention

24
Q

management of haemorrhagic stroke?

A

supportive

  • stop anticoagulants and antithrombotics e.g. clopidogrel
  • reverse anticoagulation asap
25
what is the ROSIER score used for?
to identify symptoms of stroke (exclude hypoglycaemia first) if >0, stroke is likely
26
1st line radiological investigation for suspected stroke?
non-contrast CT head
27
immediate management of acute stroke?
aspirin 300mg PO/ PR asap once haemorrhagic stroke excluded
28
T/F: AF should be immediately treated with anticoagulants if identified in a stroke patient
False- anticoagulants should not be started until brain imaging has excluded haemorrhage, and usually not until 14 days have passed from the onset of an ischaemic stroke
29
thrombolysis agent?
alteplase
30
absolute contraindications to thrombolysis?
previous haemorrhagic stroke
31
absolute contraindications to thrombolysis?
- Previous IC haemorrhage - Seizure at onset of stroke - Intracranial neoplasm - Suspected SAH - Stroke/ traumatic brain injury in preceding 3 months - LP in past 7 days - GI haemorrhage in preceding 3 weeks - Active bleeding - Pregnancy - Oesophageal varices - Uncontrolled hypertension >200/120mmHg
32
Offer thrombectomy as soon as possible and within ___ hours of symptom onset, together with ?what?, to people who have: acute ischaemic stroke and confirmed occlusion of the __ __ circulation demonstrated by what imaging
6 IV alteplase (if <4.5 hr) anterior cerebral CT/ MR-angiogram (can be up to 24 hours if imaging shows potential to salvage brain tissue e.g. limited infarct core volume)
33
Offer thrombectomy as soon as possible and within ___ hours of symptom onset, together with ?what?, to people who have: acute ischaemic stroke and confirmed occlusion of the __ __ circulation demonstrated by what imaging
6 IV thrombolysis (if <4.5 hr) proximal anterior CTA/ MRA (can be up to 24 hours if imaging shows potential to salvage brain tissue e.g. limited infarct core volume)
34
secondary prevention post stroke?
clopidogrel first line aspirin + MR dipyridamole if clopidogrel not tolerated
35
T/F: hypertensives should be routinely used post stroke
false - only in those with HTN
36
T/F: hypertensives should be routinely used post stroke
``` only if there is a hypertensive emergency: Hypertensive encephalopathy Hypertensive nephropathy Hypertensive HF/ MI Aortic dissection Pre-eclampsia/eclampsia ```
37
T/F: all stroke patients should be started on a statin
False- only if cholesterol is > 3.5 mmol/l Many physicians will delay treatment until 48 hr due to the risk of haemorrhagic transformation
38
what is Wallenberg's syndrome?
aka lateral medullary syndrome ipsilateral: ataxia, nystagmus, dysphagia, facial numbness, cranial nerve palsy e.g. Horner's contralateral: limb sensory loss
39
what is Weber's syndrome?
``` ipsilateral CN III palsy contralateral weakness (upper and lower limbs) ```
40
effects of a stroke affecting anterior cerebral artery?
contralateral hemiparesis and sensory loss | lower limb > upper
41
effects of a stroke affecting middle cerebral artery?
contralateral hemiparesis and sensory loss upper limb > lower contralateral homonymous hemianopia aphasia
42
effects of a stroke affecting posterior cerebral artery?
contralateral homonymous hemianopia with macular sparing | visual agnosia
43
what arteries are affected in weber's syndrome?
branches of the posterior cerebral artery that supply the midbrain
44
which vessels are affected in Wallenberg syndrome?
posterior inferior cerebellar artery
45
what kind of visual loss is associated with retinal/ ophthalmic artery occlusion?
Amaurosis fugax
46
a lesion in the __ artery can lead to 'locked in' syndrome
basilar
47
T/F: lacunar strokes have a strong association with hypertension
true
48
stroke of ACA affects ___ stroke of MCA affects ____ stroke of PCA affects ____
leg face vision/ arm