Stroke Part 1 Flashcards
Which regions are most affected by an MCA stroke?
lateral part of the brain, hand and face most affected
which limbs are most affected by ACA stroke
leg structures
key issues you’d find in someone with a PCA stroke
PCA= posterior = region where occipital lobe is = All about vision, recgonizing faces, issues with writing sometimes, but mainly Alexia (inability to read because of visual problem)
Stroke to the PICA can cause ____ syndrome
wallenburd syndrome/Lateral medullary syndrome: pain and temp loss to ipsilateral face and contralateral body.
A basilar stroke can lead to brainstem ischemia and aamge the pons, which can cause __ ___ syndrome
locked in syndrome– complete quadriplegia, can only move the eyes.
A vertebral artery dissection also causes locked in syndrome
Most Neurospells are actually TNAs: __ ___ attacks. Can be mistaken of TIA.
Transient neurological attacks \
Benign paroxysmal positional vertigo: crystals in inner ear that throw off vestibular system and can cause dizziness, lasting for <60s.
Often initiated by bump to head, turning in bed, sitting up lying down, etc.
Dx with Hallpike Maneuver.
Migraine Aura: visual phenomenons, diplopia, tingly arm→ can be mistaken for TIA.
T/F TIA’s are caused by acute infarction
false.
a transient episode of neurological dysfunction caused by focal brain, spinal cord or retinal ischemia, without acute infarction.
Mild strokes and TIAs are lower risk.
An acute infarction will cause a full on stroke
Key distinguishing features between central vestibular dysfunction and peripheral vestibular dysfunction
centarl: imablance, neurological symptoms/signs, bidirectional nystagmus
PeripheraL: auditory symptoms, unidirectional nystagmus, nausea and vomiting
Risk factors for ischemic stroke
hypertension ***, DM, hyperchoelsterolemia, smoking
risk factors for ICH
Hypertension ***, alcohol, cocaine, meth
risk factors for SAH:
smoking***, family history
risk factors for sinovenous thrombosis:
hormonal therapy**** hypercoaguable states like pregnancy or inhertied
CHAD265 score can be used to determine which type of treatment should be used in people with AFib to determine stroke score
C; congestive heart failure
hypertension
age
dm
prior stroke or TIA
- if a lower score, may just need ASA. But if higher score, use DOACS for afib management and carrdioembolic stroke prevention
Primary Prevention of Stroke: Targets
Treatment of hypertension→ treating hypertension reduces hemorrhagic and lacunar (ischemic) strokes the best.
Stopping smoking
Treatment of high LDL
Reduce alcohol intake, increase exercise
Anticoagulation in Afib. → use Warfarin or DOACs
- CHAD265 Score: simple prediction tool for assessing stroke risk:
- Congestive heart failure
- Hypertension
- Age
- DM
- Prior stroke or TIA.
Primary Prevention of Atheroscleorosis-related stroke
Asymptomatic ICA stenosis; younger males modestly benefit from carotid revascularization.
Primary Prevention of SAH (subarachnoid hemorrhage)
recall that SAH is primarily caused by smoking and family history
Unruptured aneurysm; screen families with first degree relatives who have had SAH. MRA preferred. Encourage smoking cessation of entire family (Encourage smoking cessation of the entire family!
>7mm aneurysm warrants consideration for clipping or coiling.
Primary Prevention of ICH
Limit alcohol intake
Avoid weight loss drugs (PPA, ephredrin)
AIS is the main type of stroke. What are the 5 broad categories of acute ischmec storke?
- large artery atherscloertic stenosis
- small artery disase (lacunar stroke)
- cryptogenic
- cardioembolic stroke
- unusual
most common cause of acute ischemic stroke
large artery atherosclerosis.
Atherosclerosis causes platelet aggregation, which is a lot of active embolization. Therefore atherosclerosis is a bunch of mini emboli, vs cardioembolic is one larger emboli.
Large arteries can harden, MCA stenosis can also happen (intracranial medium sized atherosclerosis)
MCA arteries/Intracranial stenting not safe. Too small.
2 revascularization options for large vessel atherosclerosis-stroke.
key non-surg management
Two revascularization options:
Carotid endarterectomy CEA
Carotid aortic stent. CAS–> usually done cause less invasive
Non surg management: statins, treatment of comorbid conditions like dyslipidemia, possibly EPA/fish oil derivative. Add Ezetimibe.
Rule of 6: if the dose of a statin is doubled, there is a 6% increase in LDL lowering.
Key young adult stroke
PFO related stroke: those with a patent foramen ovale (young adult stroke).
Dissections, PFOs and other rare/unusual conditions make up majority cause of strokes in young people under 60.
Treatment of PFO related stroke is to fix the PFO
Larger shunt is a risk factor. There is a clear benefit in stroke prevention with PGO closure overall in patients under 45. The larger the shunt, the more beneficial.
Number one cause of a cardioembolic stroke leading to acute ischemic stroke. Treatment?
AFIB IS THE NUMBER ONE CAUSE OF CARDIOEMBOLIC STROKE
- most cardioembolic causes are treated with warfarin, but for afib, use the CHAD265 score to determine ASA/APA vs DOAC! (DOAC USUALLY)
Lacunar/ Small Vessel Cause of Ischemia
Often occurs in basal or brainstem penetrating arteries due to __ __.
Most common in _.
__ APA is better than _ _ therapy. Also manage hypertension.
Cholesterol lowering doesn’t have the same benefit as it does in large vessel strokes.
Other→ 5% are unusual presentations like dissections, arteritis.
Lacunar/ Small Vessel Cause of Ischemia
Often occurs in basal or brainstem penetrating arteries due to hypertensive arteriolosclerosis.
Most common in ASians.
Aspirin APA is better than dual antiplatelet therapy. Also manage hypertension.
Cholesterol lowering doesn’t have the same benefit as it does in large vessel strokes.
Other→ 5% are unusual presentations like dissections, arteritis.
ICH; what sign do you see on CTA
risk factors? management?
ICH; can differentiate between other bleeds like SAH because ICHS are lobar and deep, whereas SAHs and epidural hematomas are on the outside. WOuld see a characteristic “spot sign,” which is positive for intracerebral hemorrhage
Risk factor: people on anticoagulants, people with hypertension, cocaine.
Management: correct any coagulopathies/stop any anticoagulants that could be causing them to unnecessarily bleed.
Acute lowering BP <150mmHg (no effect if you lower it more aggressively under 150), Vitamin K, and prothrombin complex concentrate (Clotting factors: FII, VII, IX and X, protein C and S), hemostasis (limited because bleeding occurs very early.
Surgery: indications are superficial lobar hemorrhage, CGS 9-12, volume 20-80ml, worsening status, young patient, high ICP, moderate or large cerebellar ICH.
