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Flashcards in stuff i cant remember Deck (48)
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1

side effects of aluminum hydroxide? 4

constipation
hypophosphatemia
weakness, osteodystrophy
seizures/encephalopathy

2

SE of calcium carbonate? 3

hypercalcemia
rebound acid
calcium stones

3

SE of Mg hydroxide? 3

diarrhea
hyporeflexia
hypotension

4

contraindications for bismuth/sucralfate?

severe renal failure
antiplateletes/coags

5

absolute contras for bismuth?

GI bleeds salicylate hypersensitivity

6

what 5HT3 antiemetic si the worst cuase QT thing?

dolasetron

7

what 5HT3 has the longest half life so its good for CINV?

palonosetron

8

What occurs in serotonin syndrome?

neuromuscular hyperacitivy, agitation,
autonomic stimulation hyperthermia, diaphoresis, diarrhea

9

Best use for aprepitant?

post op

10

what H1 receptor agonist combo is good for prengant ladies with NV of P?

doxylamine + pyridoxine (b6)

11

what 3 antiemetics have anticholinergic SE?

H1 blockers
D2 blockers
M1 blocker

12

what are the 3 D2 antagonists that arent metoclopramide?

chlopromazine, perphenazine, prochlorperazine

13

what are the two weed drugs?

dronabinol
nabilone

14

whats youe 3 drug antiemetic regiment?

5ht3 + NK1 + roid
D2 next

15

Whats the black box warning for alostetron?

ischemic colitis

16

whats the dragons blood called and whats its MOA?

crofelemer
inhibits CFTR --> no cAMP --> blocks Cl channels

17

what are the constipation tx that arent laxatives?

guanylate cyclase C agonists

periph opiod antagoinst

selective chloride channel (C2) activators

18

what is the Guanylate cyclase C agonist learned? use? MOA?

linaclotide

IBS-c

activates GCC --> increases cGMP --> increases chloride thru CFTR

19

what are the peripheral opiod antagonists? 3
whats bad bout the 3rd?

methylnaltrexone
naloxegol
alvimopan --> MI risk

20

what os the selective chloride channel activator? MOA?

lubiprostone

activates CIC 2 channels --> more secretion

21

use for lubiprostone?

IBS-c
CIC
OIC

22

interactions with osmotic saline laxatives?

diuretics, CHF, HTN, renal disease

23

what are the non senna irritants?

bisacodyl
castor oil
glycerin
sodium picosulfate

24

what are bad things about irritants?

go into boob milk, GI obstruction/ileus

25

what is procolonoscopty only?

perpopik

26

what 4 drugs are UC?

5-ASA
JAK stat inhibitors
TNF-a inhibitors
4a-intigren inhibitors

27

what are the 4 5-ASA drugs?

-sala-
mesalamine
balsalazide
osalazine
sulfasalasizne

28

what is the JAK inhibitor?

tofacitinib
UC ONLY

29

what are the TNF-a inhibitors?
which are CD, UC, both?

adalimumab (both)
infliximab (both)
golimumab (UC)
certolizumab (CD)

30

SE of TNF-a inhibotrs?

liver toxicity, infecitons

31

what are the 2 a-4 integrin inhibitors? which is used for which

vedolizumab (BOTH)
natalizumab (CD)

32

whats the big side effect with natalizumab?

JC reactivation --> PML

33

whats the IL-12/23 inhibitor?

ustekinumab

34

what is fidaxomicin? MOA?

macrolide
binds and inhuibits 50s subunit

35

what is the MOA for iodoquinol?

halogenated hydroxyguinoline, unknown

36

MOA of nitazoxanide?

inhibits ferredoxin idioreductase

37

SE of nitazoxanide?

large salivary glands
yellow eyes and yellower pee

38

what is niclosamide used for? whats its MOA?

cestode fair
inhibitrs oxphos and ATPase activity

39

praziquantel MOA?

increases membrane permeability to Ca

40

what is the MOA of ledipasvir?

viral NS5A inhibitor --> virus cant replicated

HEP C

41

what is the MOA for ribavirin? contras?

inhibitrs synth of guanin nucleotides by inhibitirng monophosphate dehydrogenase

pregnancy, anemia

42

what is the MOA for simeprevir?

HCV protease inhibitor (NS35/4A inhibitor) --> no replication

43

what is the MOA for sofosbuvir?

inhibitrs HCV RNA dependant RNA polymerase (NS5B)

HEP C

44

when can you not use INF-a for hepatitis?

decompensated cirrhosis

45

what are the nucleoSIDES for hep B? 3

entecavir (1)
lamivudine
telbivudine

46

what are the nucleoTIDES for Hep B? 2

tenofovir (1)
adefovir

47

what are the other Hep C t protease inhibitors? that arent simeprevir

telaprevir
boceprevir

48

what are the other NS5A inhibitors that arent ledipasvir?

elbasvir
velpatasfvir