Flashcards in stuff i cant remember Deck (48)
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1
side effects of aluminum hydroxide? 4
constipation
hypophosphatemia
weakness, osteodystrophy
seizures/encephalopathy
2
SE of calcium carbonate? 3
hypercalcemia
rebound acid
calcium stones
3
SE of Mg hydroxide? 3
diarrhea
hyporeflexia
hypotension
4
contraindications for bismuth/sucralfate?
severe renal failure
antiplateletes/coags
5
absolute contras for bismuth?
GI bleeds salicylate hypersensitivity
6
what 5HT3 antiemetic si the worst cuase QT thing?
dolasetron
7
what 5HT3 has the longest half life so its good for CINV?
palonosetron
8
What occurs in serotonin syndrome?
neuromuscular hyperacitivy, agitation,
autonomic stimulation hyperthermia, diaphoresis, diarrhea
9
Best use for aprepitant?
post op
10
what H1 receptor agonist combo is good for prengant ladies with NV of P?
doxylamine + pyridoxine (b6)
11
what 3 antiemetics have anticholinergic SE?
H1 blockers
D2 blockers
M1 blocker
12
what are the 3 D2 antagonists that arent metoclopramide?
chlopromazine, perphenazine, prochlorperazine
13
what are the two weed drugs?
dronabinol
nabilone
14
whats youe 3 drug antiemetic regiment?
5ht3 + NK1 + roid
D2 next
15
Whats the black box warning for alostetron?
ischemic colitis
16
whats the dragons blood called and whats its MOA?
crofelemer
inhibits CFTR --> no cAMP --> blocks Cl channels
17
what are the constipation tx that arent laxatives?
guanylate cyclase C agonists
periph opiod antagoinst
selective chloride channel (C2) activators
18
what is the Guanylate cyclase C agonist learned? use? MOA?
linaclotide
IBS-c
activates GCC --> increases cGMP --> increases chloride thru CFTR
19
what are the peripheral opiod antagonists? 3
whats bad bout the 3rd?
methylnaltrexone
naloxegol
alvimopan --> MI risk
20
what os the selective chloride channel activator? MOA?
lubiprostone
activates CIC 2 channels --> more secretion
21
use for lubiprostone?
IBS-c
CIC
OIC
22
interactions with osmotic saline laxatives?
diuretics, CHF, HTN, renal disease
23
what are the non senna irritants?
bisacodyl
castor oil
glycerin
sodium picosulfate
24
what are bad things about irritants?
go into boob milk, GI obstruction/ileus
25
what is procolonoscopty only?
perpopik
26
what 4 drugs are UC?
5-ASA
JAK stat inhibitors
TNF-a inhibitors
4a-intigren inhibitors
27
what are the 4 5-ASA drugs?
-sala-
mesalamine
balsalazide
osalazine
sulfasalasizne
28
what is the JAK inhibitor?
tofacitinib
UC ONLY
29
what are the TNF-a inhibitors?
which are CD, UC, both?
adalimumab (both)
infliximab (both)
golimumab (UC)
certolizumab (CD)
30
SE of TNF-a inhibotrs?
liver toxicity, infecitons
31
what are the 2 a-4 integrin inhibitors? which is used for which
vedolizumab (BOTH)
natalizumab (CD)
32
whats the big side effect with natalizumab?
JC reactivation --> PML
33
whats the IL-12/23 inhibitor?
ustekinumab
34
what is fidaxomicin? MOA?
macrolide
binds and inhuibits 50s subunit
35
what is the MOA for iodoquinol?
halogenated hydroxyguinoline, unknown
36
MOA of nitazoxanide?
inhibits ferredoxin idioreductase
37
SE of nitazoxanide?
large salivary glands
yellow eyes and yellower pee
38
what is niclosamide used for? whats its MOA?
cestode fair
inhibitrs oxphos and ATPase activity
39
praziquantel MOA?
increases membrane permeability to Ca
40
what is the MOA of ledipasvir?
viral NS5A inhibitor --> virus cant replicated
HEP C
41
what is the MOA for ribavirin? contras?
inhibitrs synth of guanin nucleotides by inhibitirng monophosphate dehydrogenase
pregnancy, anemia
42
what is the MOA for simeprevir?
HCV protease inhibitor (NS35/4A inhibitor) --> no replication
43
what is the MOA for sofosbuvir?
inhibitrs HCV RNA dependant RNA polymerase (NS5B)
HEP C
44
when can you not use INF-a for hepatitis?
decompensated cirrhosis
45
what are the nucleoSIDES for hep B? 3
entecavir (1)
lamivudine
telbivudine
46
what are the nucleoTIDES for Hep B? 2
tenofovir (1)
adefovir
47
what are the other Hep C t protease inhibitors? that arent simeprevir
telaprevir
boceprevir
48
