stuff i cant remember

Question 1

side effects of aluminum hydroxide? 4

Answer 1

constipation
hypophosphatemia
weakness, osteodystrophy
seizures/encephalopathy

Question 2

SE of calcium carbonate? 3

Answer 2

hypercalcemia
rebound acid
calcium stones

Question 3

SE of Mg hydroxide? 3

Answer 3

diarrhea
hyporeflexia
hypotension

Question 4

contraindications for bismuth/sucralfate?

Answer 4

severe renal failure

antiplateletes/coags

Question 5

absolute contras for bismuth?

Answer 5

GI bleeds salicylate hypersensitivity

Question 6

what 5HT3 antiemetic si the worst cuase QT thing?

Answer 6

dolasetron

Question 7

what 5HT3 has the longest half life so its good for CINV?

Answer 7

palonosetron

Question 8

What occurs in serotonin syndrome?

Answer 8

neuromuscular hyperacitivy, agitation,

autonomic stimulation hyperthermia, diaphoresis, diarrhea

Question 9

Best use for aprepitant?

Answer 9

post op

Question 10

what H1 receptor agonist combo is good for prengant ladies with NV of P?

Answer 10

doxylamine + pyridoxine (b6)

Question 11

what 3 antiemetics have anticholinergic SE?

Answer 11

H1 blockers
D2 blockers
M1 blocker

Question 12

what are the 3 D2 antagonists that arent metoclopramide?

Answer 12

chlopromazine, perphenazine, prochlorperazine

Question 13

what are the two weed drugs?

Answer 13

dronabinol

nabilone

Question 14

whats youe 3 drug antiemetic regiment?

Answer 14

5ht3 + NK1 + roid

D2 next

Question 15

Whats the black box warning for alostetron?

Answer 15

ischemic colitis

Question 16

whats the dragons blood called and whats its MOA?

Answer 16

crofelemer

inhibits CFTR –> no cAMP –> blocks Cl channels

Question 17

what are the constipation tx that arent laxatives?

Answer 17

guanylate cyclase C agonists

periph opiod antagoinst

selective chloride channel (C2) activators

Question 18

what is the Guanylate cyclase C agonist learned? use? MOA?

Answer 18

linaclotide

IBS-c

activates GCC –> increases cGMP –> increases chloride thru CFTR

Question 19

what are the peripheral opiod antagonists? 3

whats bad bout the 3rd?

Answer 19

methylnaltrexone
naloxegol
alvimopan –> MI risk

Question 20

what os the selective chloride channel activator? MOA?

Answer 20

lubiprostone

activates CIC 2 channels –> more secretion

Question 21

use for lubiprostone?

Answer 21

IBS-c
CIC
OIC

Question 22

interactions with osmotic saline laxatives?

Answer 22

diuretics, CHF, HTN, renal disease

Question 23

what are the non senna irritants?

Answer 23

bisacodyl
castor oil
glycerin
sodium picosulfate

Question 24

what are bad things about irritants?

Answer 24

go into boob milk, GI obstruction/ileus

Question 25

what is procolonoscopty only?

Answer 25

perpopik

Question 26

what 4 drugs are UC?

Answer 26

5-ASA JAK stat inhibitors TNF-a inhibitors 4a-intigren inhibitors

Question 27

what are the 4 5-ASA drugs?

Answer 27

``` -sala- mesalamine balsalazide osalazine sulfasalasizne ```

Question 28

what is the JAK inhibitor?

Answer 28

tofacitinib | UC ONLY

Question 29

what are the TNF-a inhibitors? | which are CD, UC, both?

Answer 29

adalimumab (both) infliximab (both) golimumab (UC) certolizumab (CD)

Question 30

SE of TNF-a inhibotrs?

Answer 30

liver toxicity, infecitons

Question 31

what are the 2 a-4 integrin inhibitors? which is used for which

Answer 31

vedolizumab (BOTH) | natalizumab (CD)

Question 32

whats the big side effect with natalizumab?

Answer 32

JC reactivation --> PML

Question 33

whats the IL-12/23 inhibitor?

Answer 33

ustekinumab

Question 34

what is fidaxomicin? MOA?

Answer 34

macrolide | binds and inhuibits 50s subunit

Question 35

what is the MOA for iodoquinol?

Answer 35

halogenated hydroxyguinoline, unknown

Question 36

MOA of nitazoxanide?

Answer 36

inhibits ferredoxin idioreductase

Question 37

SE of nitazoxanide?

Answer 37

large salivary glands | yellow eyes and yellower pee

Question 38

what is niclosamide used for? whats its MOA?

Answer 38

cestode fair | inhibitrs oxphos and ATPase activity

Question 39

praziquantel MOA?

Answer 39

increases membrane permeability to Ca

Question 40

what is the MOA of ledipasvir?

Answer 40

viral NS5A inhibitor --> virus cant replicated HEP C

Question 41

what is the MOA for ribavirin? contras?

Answer 41

inhibitrs synth of guanin nucleotides by inhibitirng monophosphate dehydrogenase pregnancy, anemia

Question 42

what is the MOA for simeprevir?

Answer 42

HCV protease inhibitor (NS35/4A inhibitor) --> no replication

Question 43

what is the MOA for sofosbuvir?

Answer 43

inhibitrs HCV RNA dependant RNA polymerase (NS5B) HEP C

Question 44

when can you not use INF-a for hepatitis?

Answer 44

decompensated cirrhosis

Question 45

what are the nucleoSIDES for hep B? 3

Answer 45

entecavir (1) lamivudine telbivudine

Question 46

what are the nucleoTIDES for Hep B? 2

Answer 46

tenofovir (1) | adefovir

Question 47

what are the other Hep C t protease inhibitors? that arent simeprevir

Answer 47

telaprevir | boceprevir

Question 48

what are the other NS5A inhibitors that arent ledipasvir?

Answer 48

elbasvir | velpatasfvir