substance

Question 1

LSD is derived from what

Answer 1

morning glory seeds, ergot fungus alkaloids, rye fungus

Question 2

women are less likely to smoke then men except in what ethnic group? hint: this group also has highest smoking rate among US adults

Answer 2

native americans/alaska natives

Question 3

clonidine MOA & dose for opioid WD

Answer 3

binds a2 autorec, dec locus coerueus firing, dec NE release/noradrenergic activation

Question 4

fumes/glue huffing intoxication

Answer 4

n/v, slurred speech, poor motor coordination

Question 5

DTs presentation/timeline

vs alcoholic psychosis

Answer 5

DTs = MCC new onset hallucinations. AVH, disorientation, autonomic instab/fevers, tremors, agitation. 2-4d after last drink avg duration <1w

AP = hallucinations but CLEAR sensorium

Question 6

etoh… liver dz vs cirrhosis vs hepatitis labs/bx

Answer 6

liver dz = >AST:ALT, inc GGT, low albumin, bili wnl, macrovesic fatty globules
cirrhosis = AST/ALT high or wnl/low, fibrosis, necrosis, nodules
hepatitis = inc bili

Question 7

acamprosate structure resembles what NT

Answer 7

GABA

Question 8

cocaine v amphetamine MoA

Answer 8

cocaine: inhib DA/5HT reuptake
amph: inihib DA/5HT/NE reuptake transp, VMAT2, & MAO

Question 9

classic MRI finding in methyl etoh & why

Answer 9

methyl etoh metab to formaldehyde + formate, & formate neurotoxic & accum @PUTAMEN causing infarct or hemorrhage

Question 10

MoA: naltrexone, acamprosate, disulfiram, lyrica, baclofen

Answer 10

naltrexone mu opioid rec antag
acamprosate structure like GABA, antag NMDA rec to dec glutamate fxn
disulfiram blocks DA beta hydroxylase @brain (may treat cocaine use do) & aldehyde dehydrogenase @liver (cant convert acetaldehyde to acetate for etoh use do)
lyrica Ca channel antag
baclofen GABA B agonist