Substance misuse: Illegal drugs Flashcards

(58 cards)

1
Q

What percentage of adults have tried illegal drugs in their lifetime, and how many were in the previous year?

A

33% lifetime

10% in previous year

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2
Q

What percentage of Under 25s have tried illegal drugs in their lifetime, and how many were in the previous year?

A

50% lifetime

33% in previous year

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3
Q

Name 3 risk factors for illegal drug use

A

Male (3-4:1)
Younger age (Under 25: 50%)
Lower socioeconomic class
Psychiatric illness

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4
Q

What are the 5 patterns of drug use?

A

Experimental use - typically softer drugs
Situation use - mainly stimulants and hallucinogenics
Recreational use - regular but not dependent
Dependent use
Dual diagnosis - drug users with major mental illness

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5
Q

What is the diagnostic criteria for dependence syndrome?

A

At least 3 symptoms over a 12 month period:

  • Compulsion to take substance
  • Impaired control over use
  • Salience (prioritisation above all else)
  • Tolerance
  • Withdrawal or relief use
  • Persistent use despite clear evidence of harm
  • Rapid reinstatement after abstinence
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6
Q

What are the categories of drugs of abuse?

A
Opiates
Depressants
Stimulants
Hallucinogenics
Others
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7
Q

Name 3 opiates commonly abused

A
Heroin
Methadone
Codeine
Pethidine
Buprenorphine
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8
Q

Name 3 depressants commonly abused

A

Alcohol
Benzodiazepines e.g. Diazepam
GHB

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9
Q

Name 3 stimulants commonly abused

A

Cocaine “Coke”
Amphetamines “Speed”
MDMA “Ecstasy”

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10
Q

Name 3 hallucinogenics commonly abused

A

LSD “Acid”
Mushrooms
Ketamine “Vitamin K”
PCP “Angel dust”

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11
Q

Name 3 other commonly abused drugs

A

Cannabis “Weed/Dope”
Volatile chemicals (Glues, gases and aerosols)
Anabolic steroids

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12
Q

What is the difference between opiates and opioids?

A

Opiates - naturally occurring

Opioids - synthetically produced

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13
Q

What are the desirable properties of opiates/opioids?

A

Euphoriant
Anxiolytic
Potent analgesic (medical use)

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14
Q

How can heroin be taken?

A

Smoking “Chasing”
Oral
Snorted
Parental IV, IM, or SC

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15
Q

What acute medical problems are associated with heroin?

A
Constipation
NaV
Respiratory depression
Aspiration and loss of consciousness
Death
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16
Q

Name 3 complications that may occur as a result of IVDU?

A
Local abscess
Cellulitis
Bacterial endocarditis - tends to occur in right heart
Osteomyelitis
Sepsis
Hep B and C, and HIV
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17
Q

What sign and symptoms present in heroin toxicity?

A

Coma
Respiratory depression
Mitosis - Pinpoint pupils

Track marks
Fresh puncture wounds

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18
Q

What are the early signs and symptoms of opiate withdrawal?

A
Lacrimation and sweating
Muscle ache
Agitation
Tachycardia
Hypertension
Sleep disturbance
Anxiety
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19
Q

What are the late signs and symptoms of opiate withdrawal?

A
Diarrhoea
NaV
Goosebumps
Stomach cramps
Cravings and depression
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20
Q

Outline the general management of substance misuse

A
Therapeutic alliance
Harm reduction
Substitution
Detox
Maintaining abstinence
Preventing relapse
Social recovery
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21
Q

What harm reduction steps can be taken in drug misuse?

A
Do not use while alone
Do not use with other drugs
Avoid IV route
If injecting, use safe injective advice
-Sterile needles/syringes/water
-Don't share needles
-Rotate injection site
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22
Q

What social problems are associated with illegal drug dependence?

A

Crime

Homelessness

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23
Q

Name the 2 types of drug substitution therapy, and state their indications

A

Maintenance therapy - harm reduction and stabilisation, better for longterm addicts.

Detoxification - aim to come off a drug, suitable for highly motivated individuals looking to detox from all drugs within that class. Circumstance must be stable to maintain abstinence.

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24
Q

What investigations should be done when assessing suitability for substitution therapy?

A

FBC
LFTs
ECG - QTc

25
What drugs are used in maintenance treatment of opioid withdrawal? Which is preferred in the majority of cases?
Methadone - first choice, people settle better | Buprenorphine
26
Name a contraindication to Methadone?
Long QTc interval. Methadone may prolong this and induce Torsades de points and sudden cardiac death.
27
In what situations would Buprenorphine be used over Methadone for opioid maintenance therapy?
Previous bad experiences with methadone Prefer 'clear head' response of buprenorphine over the 'clouding' of methadone and heroin Hx of relapsing whilst taking methadone Abnormal LFTs - buprenorphine is less affected by liver enzymes
28
How is compliance to opioid maintenance therapy monitored?
Urine tests
29
What drugs are used in opioid detox? What determines the drug of choice?
Methadone Buprenorphine Detox normally uses same opioid as that in maintenance.
30
What important safety advice should be given whilst a patient is undergoing opioid detox?
Advise about the risks of overdose due to loss of tolerance. This risk may be potentiated by use of alcohol or benzodiazepines.
31
How quickly do withdrawal symptoms appear in opiate-dependent individuals? How long does withdrawal last?
6-24hrs after last dose | Withdrawal typically lasts 5-7 days
32
What is the mechanism of action of Methadone?
Long-acting full mu-opioid agonist. 24hr half-life, OD
33
Why is methadone the first choice of treatment for opioid dependency?
Long-acting opiate taken OD - increases compliance Full agonist of opioid receptors Cannot be injected due to high viscosity
34
What is the mechanism of action of Buprenorphine?
Partial opiate agonist.
35
What medication can be prescribed to prevent opioid relapse?
Naltrexone - opiate antagonist
36
What are the desirable effects of antidepressants?
*GABA Receptor agonists* Anxiolytic Relaxant Counteracts side-effects of other drugs Hypnotic Anticonvulsant
37
How can benzodiazepines be taken?
Orally | Injection
38
What acute medical problems are associated with benzodiazepines?
Forgetfulness Drowsiness Impaired concentration and coordination Increased risk of accidents
39
How does benzodiazepine overdose present?
``` "Classic" isolated OD: Coma with normal vital signs Dizziness Confusion Drowsiness Anxiety and agitation ```
40
Name 3 symptoms of benzodiazepine withdrawal
``` Anxiety and agitation Depression Insomnia Tremor Headache and nausea Depersonalisation ``` Can be complicated by seizures and delirium
41
What are the main reasons for prescribing less benzodiazepines in primary care?
Tolerance | Dependence
42
What drug is used in substitute prescribing of benzodiazepine dependency?
Diazepam, for is long half-life and variety of strengths and formulations.
43
What is the mechanisms of action of Diazepam?
Long-acting GABA agonist
44
When do withdrawal symptoms appear in benzo-dependent individuals?
Appear within 24hr of last short-acting benzodiazepine, may be up to 3 weeks for long-acting benzodiazepines.
45
What are the route of cocaine abuse?
Inhaled/snorted Injected Smoked - crack cocaine
46
What are the desirable effects of cocaine?
Increased alertness and endurance Diminished need for sleep Euphoria Confidence Local anaesthetic at mucous membranes
47
Name 2 acute medical problems associated with cocaine
Arrhythmias Intense anxiety Hypertension ➔ stroke Impulsivity and impaired judgement
48
Name 2 chronic medical problems associated with cocaine
Necrosis of nasal septum Foetal damage Panic and anxiety disorders Psychosis - esp persecutory delusions
49
Outline the management of cocaine abuse
Harm reduction advice. Cocaine is not associated with dependence, so there is no role for substitute prescribing.
50
How is MDMA taken?
Orally
51
What is the mechanism of action of MDMA?
Causes serotonin release, and inhibits reuptake
52
What are the desirable effects of MDMA?
Feeling of increased camaraderie Pleasurable agitation Hallucinations Decreased fatigue - stimulant properties
53
Name 2 acute medical problems associated with MDMA
Increased sweating ➔ deaths associated with dehydration Nausea Vomiting Decreased potency despite increased libido
54
Outline the management of MDMA abuse
Harm reduction advice. MDMA is not associated with dependence, so there is no role for substitute prescribing.
55
How can cannabis be taken?
Smoked | Eaten
56
What are the immediate effects of cannabis?
``` Mild euphoria - giggles Sense of enhanced wellbeing Relaxation Altered time sense Increased appetite - munchies ```
57
Name 2 acute medical problems associated with cannabis?
Mild paranoia Panic attacks Accidents due to delayed reaction time
58
Why is it important to ask specifically about cannabis in psychiatry?
Cannabis use can precipitate an episode or relapse of schizophrenia. Regular use is associated with paranoid ideation and other psychotic features.