SUM - CH8 - Fluids 2: Flashcards
Hypotonic + Mild Hyponatremia (120-130) treatment
Restrict water
Hypotonic + Moderate hyponatremia (110-120) treatment
Loop diuretics + Saline (to prevent renal concentration with ADH)
Hypotonic + Severe hyponatremia (<110): Treatment
Give hypertonic saline to increase 1 - 2 mEq/L/h
Hypovolemic + Hypernatremia: Treatment
Isotonic NaCl to restore hemodynamics. Correction of Na+ can wait, until hemodynamically stable. Then replace free water deficit
Isovolemic + hypernatremia: Treatment
Oral fluids or D5W
Hypervolemic + Hypernatremia: Treatment
Diuretics + D5W (dialyze patients with renal failure)
Ionized Calcium calculation
= Total Ca++ - (Albumin*0.8)
Hypomagnesemia and Ca+
Decreased Mg –> decreased PTH –> Decreased Ca++
Chvostek’s sign
Tapping facial nerve leads to twitching of facial muscles in hypocalcemia
Trousseau’s sign
Inflate BP cuff > Systolic for 3 min –> carpal spasm
Hypocalcemia: S/S (2)
- Neuromuscular irritability (hyperactive reflexes, tetany, grand mal seizures)
- Arrythmias / Prolonged QT
Hypocalcemia: Diagnosis (3)
- BUN, Cr, Mg, Albumin, Ionized Ca++
- PO4
- PTH
Hypocalcemia: treatment (3)
- Emergency: Ca++ gluconate
- Long term: Ca++ / Vit. D suppliments
- PTH def: give Ca++ suppliment with thiazide * also important to correct Mg
Milk-Alkali syndrome
Ca++ based antacids –> hypercalcemia and Alkalosis
Lithium & Ca++
Lithium –> PTH in some pts –> Hyper Ca++
Hypercalcemia: S/S
Stones
- nephrocalcinosis/nephrolithiasis
Bones (Osteitis fibrosa cystica)
Groans
- Muscle aches,
- pancreatitis,
- PUD,
- Constipation,
- Gout
Psychiatric overtones
- Depression,
- fatigue,
- anorexia,
- sleep disturbance,
- anxiety
Other
- polyuria,
- HTN,
- Weight loss,
- Shortened QT
Urinary cAMP levels
Markedly elevated in primary hyperparathyroidism
Hypercalcemia: treatment
- osteoclastic disease
- Vit. D overload - renal failure
- Increase urinary excretion:
- IV fluids [NS],
- Loop diuretics
- Inhibit bone resorption in pts with osteoclastic disease:
- bisphosphonates,
- Calcitonin
- Glucocorticoids if Vit. D dependent mechanism or MM
- Hemodyalysis in renal failure pts.
Hypokalemia: S/S (7)
- Arrythmias (prolongs normal conduction)
- Muscle weakness, fatigue, paralysis, cramps
- Decreased DTR
- Paralytic ileus
- Polyuria / polydipsia
- Digitalis tox
- Flattening of T-wave (if severe U-wave appears)
Hypokalemia: treatment
KCl
Hypokalemia: Causes
- GI Losses
- Renal losses
- Diuretics,
- hyperaldosteroinism,
- Excessive glucocorticoids
- Magnesium deficiency
- Bartter’s syndrome
- Other: Epinephrine / insulin
Hyperkalemia: S/S
- Arrythmia: Peaked T-waves, Widened QRS, Widened PR interval, loss of P-waves, Sine wave pattern
- Muscle weakness,
- Decreased DTR
- Respiratory failure
HyperKalemia: Treat
- If severe (EKG changes): Give Ca++ IV to stabolize cellular membranes
- Shift into cells: Insulin / Glucose (if severe sodium bicarb)
- Remove K+ from body
- Kayexelate - GI potassium exchange resin
- Hemodialysis - only intractable hyperkalemia
- Diuretics
Hypomagnesemia: Causes
- GI causes (malabsorption)
- Alcohol
- Renal causes
- SIADH,
- Bartters sydnrome,
- Gentamicin, amphotericin B, Cisplatin
- Other:
- Post-parathyroidectomy,
- DKA, Thyrotoxicosis,
- Lactation,
- pancreatitis