summarising key points

Question 1

key points for alkylating agents (cyclophosphamide, ifosfamide, melphalan)

Answer 1

urothelial toxicity

increased risk of permanent male sterility

Question 2

key points for anthracyclines (doxorubicin, daunarobucin, epirubicin, idarubicin)

Answer 2

ruby red urine

formulations not interchangeable

cardiotoxic SEs

liposomal - reduces cardiotoxicity
- prevent skin eruption by cooling hands/feet, avoid gloves

Question 3

key points for antimetabolites (fluorouracil, methotrexate, mercap)

Answer 3

mucositis

myelosuppression

Question 4

key points for cytotoxic antibiotics (bleomycin, mitomycin)

Answer 4

progressive pulmonary fibrosis

pulmonary toxicity

Question 5

key points for taxanes (carbazitaxel, paclitaxel)

Answer 5

hypersensitivity reactions - premedicate with corticosteroids and antihistamines

monitor cardiac output

monitor signs and symptoms of pneumonitis and sepsis

Question 6

key points for vinca alkaloids (vincristine, vinblastine, vindesine)

Answer 6

IV only

intrathecal is fatal

bronchospasm

neurotoxicity - neuropathy, motor weakness, myalgia