Summary of Resistance Mechanisms Flashcards by Brittany Galloway

Q

Beta-lactams Examples

A

Penicillins

cephalosporins

carbapenems

monobactams

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Q

Beta-lactams Resistance Mechanism

A

Hydrolysis (β-lactamase);

altered target site

efflux

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Q

Aminoglycosides Examples

A

Gentamicin, tobramycin,

amikacin

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Q

Aminoglycosides Resistance Mechanism

A

Aminoglycoside-modifying enzymes

altered target site

efflux

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Q

Glycopeptides Example

A

Vancomycin

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Q

Glycopeptides Resistance Mechanism

A

Altered cell wall precursors

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Q

Lipopeptides Examples

A

Daptomycin

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Q

Lipopeptide Resistance Mechanism

A

Altered target site

thickening peptidoglycan structure

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Q

Tetracyclines Examples

A

Doxycycline, minocycline

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Q

Tetracyclines Resistance Mechanism

A

Altered target site

efflux

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Q

Glycylcycline Examples

A

Tigecycline

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Q

Glycylcycline Resistance Mechanism

A

Altered target site

efflux

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Q

Macrolides Examples

A

Erythromycin

azithromycin

clarithromycin

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Q

Macrolides Resistance Mechanism

A

Altered target site

efflux

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Q

Lincosamides Examples

A

Clindamycin

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Q

Lincosamides Resistance Mechanism

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A

Altered target site

efflux

Q

Streptogramins Examples

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A

Quinupristin/dalfopristin

Q

Streptogramins Resistance Mechanism

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A

Altered target site

efflux

acetylation

Q

Oxazolidinones Examples

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A

Linezolid

tedizolid

Q

Oxazolidinones Resistance Mechanism

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A

Altered target site

efflux

Q

Fluoroquinolones Examples

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A

Ciprofloxacin

levofloxacin

moxifloxacin

Q

Fluoroquinolones Resistance Mechanism

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A

Altered target site

efflux

Q

Pyrimidines Examples

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A

Trimethoprim

Q

Pyrimidines Resistance Mechanism

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A

Altered target site

efflux

Sulfonamides Examples

Sulfamethoxazole

Sulfonamides Resistance Mechanism

Altered target site efflux

Rifamycins Examples

Rifampin

Rifamycins Resistance Mechanism

ADP-ribosylation altered target site efflux

Cationic peptides Examples

Colistin polymyxin B

Cationic peptides Resistance Mechanism

Altered target site efflux