Supportive Care During Cancer Chemotherapy Flashcards Preview

PBR: Hematology > Supportive Care During Cancer Chemotherapy > Flashcards

Flashcards in Supportive Care During Cancer Chemotherapy Deck (8)
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1

How do you manage fever in a patient on chemotherapy?

Children with fever must be emergently evaluated for bacterial sepsis and other invasive infection. Give broad-spectrum antibiotics as soon as cultures are obtained.

2

What prophylactic antibiotic is prescribed to patients undergoing chemotherapy?

Trimethoprim/sulfamethoxazole (Bactrim) is prescribed as prophylaxis against Pneumocystis pneumonia.

3

Which vaccines are contraindicated for children receiving chemotherapy?

Live viral vaccines are contraindicated during treatment.

4

What is tumor lysis syndrome?

Tumor lysis syndrome is a medical emergency and describes the metabolic complications of rapid cell lysis noted with the initiation of chemotherapy or with high cell turnover with certain tumors.

5

Which (4) electrolyte abnormalities are characteristic of tumor lysis syndrome?

Hyperkalemia, hyperphosphatemia, hypocalcemia, and hyperuricemia.

6

Which three malignancies have high cell turnover which predisposes to tumor lysis even before chemotherapy initiation?

Burkitt lymphoma, T-cell ALL, and AML with hyperleukocytosis.

7

What therapies are used to prevent tumor lysis syndrome in at-risk patients?

Hyperhydration with fluids that do not contain potassium and administration of allopurinol, which prevents the formation of uric acid.

8

Why must blood products be irradiated in patients undergoing chemotherapy?

Irradiation of blood products helps to prevent life-threatening graft-vs-host disease.