Surgery Flashcards
(41 cards)
Syndrome when inadequate amount of circulating cortisol and aldosterone
Adrenal Insufficiency
CRH acts on?
ACTH
ACTH acts on?
Zona Fasiculata of Adrenal Glands
Major Glucocorticoid?
Cortisol
Nutritional Formulas:
Fat Content increase to 50% and reduction of carbohydrates
Pulmonary Failure Formula
- reduce Co2 production alleviate ventillation burden
Nutritional Formulas:
Essential AA, lower Ng, Phos, Mg, high non protein calorie, nitrogen ratio 150:1, no vitamins and elements
Renal Failure Formulas
Nutritional Formulas:
50% of protein - branched chain AA ( valine, leucine, isoleucine)
Hepatic Failure Formulas
best Resuscitate fluid?
Lactate Ringer’s Solution
Clotting Factor common to both extrinsic and intrinsic
Factor 10
- Vascular Phase ( Vasoconstriction)
- Platelet Phase ( Platelet aggregation)
- Coagulation Phase (Clot Formation)
- Fibrinolysis ( Clot Retraction & Clot Destruction)
4 major physiologic events of hemostasis
- Failure of production - impaired bone marrow function
- Decrease survival of platelet
- Sequestration
Quantitative Disorder of Platelets
- Massive Transfusion
- Therapeutic platelet inhibitors
- Disease state ( Myeloproliferative disorders, Monoclonal gammopathies, Liver dse)
Qualitative Disease of Platelets
Warfarin: extrinsic pathway
Prothrombin time
Heparin: Intrinsic pathway
Partial thromboplastin time
Treatment for PT
Vitamin K and FFP
Treatment for PTT
Protamine Sulfate
Aspirin/NSAIDs: Platelet Disorder
Bleeding Time
Factor Xa inhibitor
Rivaroxaban, Apixaban
Antidote of Rivaroxaban and Apixaban
Andexanet
Indirect Factor Xa inhibitor and Antithrombin III increase
Fondaparinux
Indirect Thrombin (IIa) Inhibitors which increase Antithrombin III
Heparin, LMWH
Direct Thrombin Inhibitors ( Factor IIa)
Argatroban, Dabigatran, Bivalirubin
Argatroban, Dabigatran, Bivalirubin Antidote
Idarucizumab
Leading cause of transfusion related deaths
Transfusion-related acute lung injury