Sweatman: Sedative Hypnotics

Question 1

BNZO’s used as anxiolytics

used routinely

Answer 1

ALprazolam
Chlordiazepam
Clonazepam
Clorazepate
Diazepam
Lorazepam
Oxazepam
Prazepam

Question 2

NON-BNZO’s used as anxiolytics

Answer 2

Buspirone

Propranolol

Question 3

drugs not used routinely because lack durability because of very short half life
would reuire inconvenient dosing regimens

Answer 3

Estazolam
Flurazepam
Quazepam
Temazepam
Triazolam

Question 4

GABA receptor promotes what upon activation

Answer 4

CL influx-hyperpolarization

Question 5

allosteric agonist

Answer 5

Benzos

Question 6

benxo MOA

Answer 6

potentiates the effects of GABA (endogenous)-does NOT change efficacy, does increas potency of endogenous GABA

Question 7

competitive antagonist of gaba receptor

Answer 7

flumazenil-used to emergency situations to alleviate the respiratory depression of benzos

Question 8

do bnzos activate GABA receptor directly

Answer 8

no but barbs do at high doses

Question 9

GABA, BNZOS and FLumazenil all act at

Answer 9

GABA receptor at alpha subunit in differnt locations

multimeric chloride channel

Question 10

barbiturates MOA

Answer 10

increase the efficacy of endogenous GABA by prolnging the binding time of GABA on the receptor

Question 11

lethal in high doses

Answer 11

BARBITURATES

Question 12

not lethal in high doses

Answer 12

BENZOES except if used with ETOH

Question 13

metabolized to nordiazepam-thus these all have a long half life-long duration of clinical effect

Answer 13

clorazepate
diazepam
chlordiazepoxide
prazepam
halezepam

Question 14

B ENZO’s with long duration of clinical effect

Answer 14

clorazepate
diazepam
chlordiazepoxide
prazepam
halezepam

Question 15

benzos with simpler metabolism and thus a short duration of clinical action

Answer 15

Lorazepam
alprazolam
oxazepam

Question 16

BENZOES THAT DO NOT UNDERG HEPATIC METABOLISM

Answer 16

LORAZEPAM

OXAZEPAM

Question 17

DRUGS WITH NO POTENTIAL FOR CYP INTERACTIONS

Answer 17

LORAZEPAM

OXAZEPAM

Question 18

loss of effect or intensitifed effect due to drug drug interactions will not therefore be seen with with benzoes

Answer 18

oxazepam (serax) and lorazepam (ativan)

Question 19

metaboliszed through UGT glucuronidation

Answer 19

oxazepam and lorazepam

Question 20

benzos are pregnancy category

Answer 20

d-contraindicated

Question 21

drugs that work over 48 hours -long

Answer 21

chlordiazepoxide
clorazepate
diazepam
flurazepam
prazepam

Question 22

drugs that work for 10-36 hours-intermediate

Answer 22

alprazolam
lorazepam
temazepam

Question 23

drugs that work for less than 10 hours-short

Answer 23

clonazepam
oxazepam
triazolam

Question 24

rapid onset

Answer 24

clorazepate-long
diazepam-long
flurazepam-long
triazolam-intermed

Question 25

injection benzos

Answer 25

diazepam | lorazepam

Question 26

intermediate onset benzos

Answer 26

alprazolam-intermed chlordiazepoxide-long clonazepam-short lorazepam-intermed

Question 27

slow onset benzos

Answer 27

oxazepam-short prazepam-long temazepam-intermed

Question 28

onset and severity of BNX withdrawl=

Answer 28

inversely related to duration of action

Question 29

short half life drugs that should be TAPERED

Answer 29

clonazepam oxazepam triazolam alprazolam estrazolam triazolam-mother fucking swetmans shit doesnt add up

Question 30

only drug that inhibits monosynaptic reflexes in the spinal cord-causes muscle relaxation

Answer 30

diazepam

Question 31

other benzos at supra clinical doses cause muscle relaxation via

Answer 31

polysynaptic blockade`

Question 32

alcohol withdrawl and liver impairment

Answer 32

lorazepam-no cyp

Question 33

alcohol withdrawl and liver is functiionally normal

Answer 33

chlodiazepoxide and diazepam

Question 34

tx of anxiety

Answer 34

4-8 week tx alprazolam lorazepam clonazepam

Question 35

tx of panic attacks

Answer 35

alprazolam

Question 36

possesses antidepressant activity like TCA

Answer 36

alprazolam

Question 37

first sign of tolerance to develop

Answer 37

sedative and hypnotic effect

Question 38

second sign of tolerance to develop

Answer 38

anticonvulsant effects

Question 39

rarely tolerance develops to

Answer 39

anxiolysis

Question 40

means of tolerance to benzos

Answer 40

receptor uncoupling or down regulation upregulation of the fast acting opposition GLUTAMATE -may be responsible cross talk from other g protein receptor systems this includes-dopa, ach, serotonin phosphorylate GABA subunits

Question 41

next morning dysfunction seen with long acting benzos such as

Answer 41

``` chlordiazepoxide clorazepate diazepam flurazepam prazepam ```

Question 42

buspirone MOA

Answer 42

supresses serotonergic while enhancing NA and DA activites

Question 43

effective as bnz at anxioysis but does nothing else no anticonvulsant, muscle relaxant, or sedative hypnotics

Answer 43

buspirone

Question 44

takes weeks to show effect very slow onset

Answer 44

buspirone

Question 45

stage fright

Answer 45

propranolol supresses autonomic symptoms does not alter emotional symptoms