sweet syndrome

Question 1

gender

Answer 1

female predominanxe.
>50 yo - more equal.
Cases associated with malignancy have one is to one ratio.

Question 2

A recurrent

Febrile dermatosis in women

Answer 2

Sweet syndrome.

Question 3

Pathogenesis

Answer 3

The classic type which is the majority of cases associated with neoplasia 3 to 35% of cases,
cases associated with inflammatory disease 3 to 16%,
cases associated with pregnancy 1- 4%,
drug induced case is exist as well 1-26%

sweet- NIPD

Question 4

most common patho Genesis of sweet syndrome.

Answer 4

Neoplasia (3-35%)

Question 5

what is the primary skin lesion

Answer 5

Sharply marginated rapidly extending tender erythematous or violations painful elevated plaque 2 to 10 cm in diameter. lesions may appear intenseley edematous juicy or merely indurated. they typically involve the face neck upper trunk and extremities. lesions may burn but do not itch. may develop pseudovesiculation and pustulation as a result of intense there will implement or infiltrate and edema

Question 6

how many percent of patients have Pathergy or koebnerization?

Answer 6

25-30%

Question 7

more than 3/4 of sweet syndrome patients have systemic findings the most common one is

Answer 7

Fever (50-80%)

Question 8

Lab findings

Answer 8

Elev ESR 90%
neutrophilia 70
leukocytosis 60
left shift inc bands 50

pxs With complete blood count them may be more likely have an underlying malignancy

Question 9

Histologic hallmark of sweet syndrome

Answer 9

nodular and diffuse dermal infiltrate of neutrophils w karyorrhexis and massive papillary dermal edema.
leukoclastic vasculitis may be present focally.

SWEET- NKP

Question 10

The majority of cases of sweet syndrome follow what disease or kind of knfection

Answer 10

URI

or viral gastroenteritis.

Question 11

blood abnormality Found in 93% of men and 71% of women with malignancy associated sweet syndrome

Answer 11

Anemia

Question 12

which drug has been associated with sweet like reactions in the skin

Answer 12

G- CSF

Question 13

How many major criteria and minor criteria for the diagnosis

Answer 13

2 major criteria and 2 minor criteria

Question 14

major criteria for dx.

Answer 14

1
abrupt onset of erythematous plaques or nodules occ w vesicles pustules bulla
2. Nodulsr and diffuse neutrophilic infiltration in the derms w karyorrhexis and massive papillary dermal edema

Question 15

Standard treatment

Answer 15

Systemic steroids with approximately 1 to 2 mg per kilogram per day of oral prednisone

Question 16

Neutrophilic dermatosis of the dorsal hands lesions

Answer 16

Edematous pustular or ulcerative nodules or plaques localized to dorsal hands.

Question 17

Present w small red ppules expand to urticarial targetoid plaques w hypopigmented centers.
Histo: neutrophilic dermatosis.

Answer 17

Marshall syndrome

occur primarily on children.