Syphilis (Treponema pallidum) Flashcards

1
Q

Venereal syphilis

A

T. pallidum ss pallidum

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2
Q

Yaws

A

T. pallidum ss pertenue

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3
Q

Bejel

A

T. pallidum ss endemicum (aka endemic syphilis)

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4
Q

Pinta

A

T. pallidum ss carateum

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5
Q

Syphilis: Chancre and regional lymphadenitis

A

Primary syphilis

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6
Q

Syphilis: Painless papule appears at site of entry ___ after inoculation

A

2-6 weeks

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7
Q

Clean, painless, highly contagious ulcer with raised borders

A

Chancre

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8
Q

T/F Chancre is highly contagious

A

T

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9
Q

Symptoms related to spirochetemia

A

Secondary syphilis

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10
Q

Secondary syphilis symptoms are noted when

A

2-10 weeks after chancre heals

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11
Q

Syphilis: Generalized non-pruritic maculopapular rash, notable involving the palms and soles

A

Secondary syphilis

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12
Q

Condyloma lata

A

Secondary syphilis

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13
Q

Gray-white to erythematous wartlike plaques in moist areas around the anus and vagina

A

Secondary syphilis (condyloma lata)

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14
Q

Meningitis occurs in ___% of patients with syphilis characterized by CSF pleocytosis and elevated protein

A

30

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15
Q

Syphilis: Relapses can occur with secondary manifestations when

A

Early latent period

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16
Q

Asymptomatic late syphilis

A

Late latent period

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17
Q

Symptomatic late syphilis

A

Tertiary syphilis

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18
Q

Gummas

A

Tertiary syphilis

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19
Q

Syphilis: Neurologic, cardiovascular, and gummatous lesions

A

Tertiary syphilis

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20
Q

Nonsuppurative granulomas of the skin and musculoskeletal system resulting from host’s hypersensitivity reaction

A

Tertiary syphilis

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21
Q

Untreated syphilis during pregnancy has a vertical transmission rate approaching ___

A

100%

22
Q

Early signs of congenital syphilis are analogous to the ___ stage of acquired syphilis

A

Secondary

23
Q

Characteristic anemia in congenital syphilis

A

Coombs’ negative hemolytic anemia

24
Q

Osteochondritis and periostitis of long bones (rarely the skull) and a mucocutaneous erythematous maculopapular or vesiculobullous lesions followed by desquamation of the hands and feet in a neonate

A

Congenital syphilis

25
Q

Persistent rhinitis or snuffles in a neonate

A

Congenital syphilis

26
Q

Metaphyseal demineralization of the medial aspect of the proximal tibia

A

Wimbergerr’s lines (congenital syphilis)

27
Q

Painful osteochondritis seen in congenital syphilis resulting in irritability and refusal to move involved extremity

A

Pseudoparalysis of Parrot

28
Q

Late manifestations of congenital syphilis seen in children >2 years of age result primarily from

A

Chronic granulomatous inflammation of bone, teeth, and CNS

29
Q

Syphilis: Bony prominence of the forehead due to persistent or recurrent periostitis

A

Olympian brow

30
Q

Syphilis: Unilateral or bilateral thickening or the sternoclavicular third of the clavicle

A

Higoumenakis sign

31
Q

Syphilis: Anterior bowing of the midportion of the tibia

A

Saber shins

32
Q

Syphilis: Convexity along the medial border of the scapula

A

Scaphoid scapula

33
Q

Syphilis: Peg-shaped upper central incisors

A

Hutchinson teeth

34
Q

Syphilis: Abnormal 1st lower molars characterized by small biting surface and excessive number of cusps

A

Mulberry molars

35
Q

Syphilis: Depression of the nasal root with destruction of bone and cartilage from syphilitic rhinitis

A

Saddle nose

36
Q

Syphilis: Linear scars that extend in a spoke-like pattern from previous mucocutaneous fissures of the mouth, anus, and genitalia

A

Rhagades

37
Q

Syphilis: Latent meningovascular infection, rare, and typically occursduring adolescence with behavioral changes, focal seizures, or loss of intellectual function

A

Juvenile paresis

38
Q

Syphilis: Rare spinal cord involvement and cardiovascular involvement with aortitis

A

Juvenile tabes

39
Q

Syphilis: Hutchinson triad

A

Hutchinson teeth, interstitial keratitis, 8th nerve deafness

40
Q

Syphilis: Unilateral or bilateral PAINLESS joint swelling (usually involving the knees) due to synovitis with sterile synovial fluid

A

Clutton joint

41
Q

Diagnosis of primary syphilis is confirmed with

A

Dark field microscopy or direct fluorescent antibody testing

42
Q

Specimen that can be used for diagnosis of primary syphilis

A

Skin lesions, placenta, umbilical cord

43
Q

Principal means for diagnosis of syphilis

A

Serologic testing

44
Q

Sensitive nontreponemal tests for syphilis

A

RPR and VDRL

45
Q

VDRL and RPR detect

A

Antibodies against phospholipid antigens on treponeme surface that cross-react with mammalian cardiolipin-lecithin-cholesterol antigen

46
Q

DOC for syphilis

A

Penicillin

47
Q

Acute systemic febrile reaction due to massive release of endotoxin-like antigen during bacterial lysis in patients with syphilis treated with Penicillin

A

Jarisch-Herxheimer reaction

48
Q

Jarisch-Herxheimer reaction occurs in ___% of patients treated with Pen

A

15-20%

49
Q

T/F Jarisch-Herxheimer reaction is an indication to discontinuing penicillin therapy

A

F

50
Q

Persons exposed >90 days before diagnosis in a sex partner of a person with syphilis should be treated if

A

Seropositive OR serologic test not available